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Free radicals, antioxidants, and human disease: where are we now?
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Oxygen radicals and human disease.
Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disorders. We discuss the chemistry of oxygen radical production and the roles of iron and ofExpand
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Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
Nitric oxide (˙NO) plays a central role in the pathogenesis of diverse inflammatory and infectious disorders,. The toxicity of ˙NO is thought to be engendered, in part, by its reaction withExpand
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Oxygen-derived species: their relation to human disease and environmental stress.
Free radicals and other reactive oxygen species (ROS) are constantly formed in the human body, often for useful metabolic purposes. Antioxidant defenses protect against them, but these defenses areExpand
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Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite
Involvement of peroxynitrite (ONOO−) in inflammatory diseases has been implicated by detection of 3-nitrotyrosine, an allegedly characteristic protein oxidation product, in various inflamed tissues.Expand
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Bloom and Fawcett: A Textbook of Histology
Seven decades of medical students have had the pleasant acquaintance of A Textbook of Histology , originally by Maximov and Bloom in 1930 and, since 1962, by Bloom and Fawcett. As in previousExpand
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Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation.
A detailed evaluation of the antioxidant and pro-oxidant properties of lipoic acid (LA) and dihydrolipoic acid (DHLA) was performed. Both compounds are powerful scavengers of hypochlorous acid, ableExpand
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Oxidants, antioxidants, and respiratory tract lining fluids.
Respiratory tract lining fluids (RTLFs) are a heterogeneous group of substances covering the respiratory tract epithelial cells (RTECs) from nasal mucosa to alveoli. Antioxidant contained in theExpand
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Determination of low-molecular-mass antioxidant concentrations in human respiratory tract lining fluids.
Antioxidants present within lung epithelial lining fluids (ELFs) constitute an initial line of defense against inhaled environmental oxidants such as ozone, nitrogen oxides, and tobacco smoke, butExpand
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