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Differential Regulation of Gene Expression by PITX2 Isoforms*
Three major PITX2 isoforms are differentially expressed in human, mice, zebrafish, chick, and frog tissues. To demonstrate differential regulation of gene expression by these isoforms we used threeExpand
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PITX2 Isoform-specific Regulation of Atrial Natriuretic Factor Expression
PITX2 and Nkx2.5 are two of the earliest known transcriptional markers of vertebrate heart development. Pitx2–/– mice present with severe cardiac malformations and embryonic lethality, demonstratingExpand
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Brain Human Monoclonal Autoantibody from Sydenham Chorea Targets Dopaminergic Neurons in Transgenic Mice and Signals Dopamine D2 Receptor: Implications in Human Disease
How autoantibodies target the brain and lead to disease in disorders such as Sydenham chorea (SC) is not known. SC is characterized by autoantibodies against the brain and is the main neurologicExpand
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Cutting Edge: Cardiac Myosin Activates Innate Immune Responses through TLRs1
Autoimmune attack on the heart is linked to host immune responses against cardiac myosin, the most abundant protein in the heart. Although adaptive immunity is required for disease, little is knownExpand
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Cardiac myosin-Th17 responses promote heart failure in human myocarditis.
In human myocarditis and its sequela dilated cardiomyopathy (DCM), the mechanisms and immune phenotype governing disease and subsequent heart failure are not known. Here, we identified a Th17 cellExpand
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Tubulin Is a Neuronal Target of Autoantibodies in Sydenham’s Chorea1
Sydenham’s chorea is a CNS disorder and sequela of group A streptococcal infection where deposition of Abs in brain may result in movement and neuropsychiatric abnormalities. We studied human mAbsExpand
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A molecular basis for differential developmental anomalies in Axenfeld-Rieger syndrome.
Pitx2, a bicoid-like homeodomain transcription factor and Dlx2 are two transcriptional markers observed during early tooth development. PITX2 binds to bicoid and bicoid-like elements in the Dlx2Expand
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Autoimmunity against dopamine receptors in neuropsychiatric and movement disorders: a review of Sydenham chorea and beyond
Antineuronal autoantibodies are associated with the involuntary movement disorder Sydenham chorea (SC) and paediatric autoimmune neuropsychiatric disorders associated with streptococcal infectionsExpand
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Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/β-catenin signaling
Homeodomain (HD) transcriptional activities are tightly regulated during embryogenesis and require protein interactions for their spatial and temporal activation. The chromatin-associated highExpand
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Antineuronal antibodies in a heterogeneous group of youth and young adults with tics and obsessive-compulsive disorder.
BACKGROUND AND OBJECTIVE Antineuronal antibodies have been implicated in tic and obsessive compulsive disorders (OCD) associated with group A streptococcal infections. We investigated antineuronalExpand
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