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A systematic nomenclature for carbohydrate fragmentations in FAB-MS/MS spectra of glycoconjugates
A summary of the ion types observed in the Fast Atom Bombardment Mass Spectrometry (FAB-MS) and collision induced decomposition (CID) MS/MS spectra of glycoconjugates (glycosphingolipids,Expand
Software tool for researching annotations of proteins: open-source protein annotation software with data visualization.
The Software Tool for Researching Annotations of Proteins (STRAP), a user-friendly, open-source C# application that automatically obtains gene ontology (GO) terms associated with proteins in a proteomics results ID list using the freely accessible UniProtKB and EBI GOA databases. Expand
The Meningococcal Vaccine Candidate GNA1870 Binds the Complement Regulatory Protein Factor H and Enhances Serum Resistance
The hypothesis that inhibiting the binding of a complement down-regulator protein to the neisserial surface by specific Ab may enhance intrinsic bactericidal activity of the Ab is supported, resulting in two distinct mechanisms of Ab-mediated vaccine efficacy. Expand
Abnormal proteins can form aggresome in yeast: aggresome‐targeting signals and components of the machinery
  • Yan Wang, A. Meriin, +4 authors M. Sherman
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 1 February 2009
It is demonstrated that in yeast a single aggregate formed by the huntingtin exon 1 with an expanded polyglutamine domain (103QP) represents a bona fide aggresome that colocalizes with the spindle pole body (the yeast centrosome) in a microtubule‐dependent fashion. Expand
Tandem mass spectrometry.
  • C. Costello
  • Chemistry, Medicine
  • Methods in molecular biology
  • 1993
A brief survey of tandem mass spectrometry as it is employed for the elucidation of several important compound types is presented here, using examples from the author's research and collaborations. Expand
Glycosylphosphatidylinositol anchors of Plasmodium falciparum: molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis.
Absence of a persistent anti- GPI antibody response correlated with malaria-specific anemia and fever, suggesting that anti-GPI antibodies provide protection against clinical malaria. Expand
A common open representation of mass spectrometry data and its application to proteomics research
The 'mzXML' format is introduced, an open, generic XML (extensible markup language) representation of MS data that will facilitate data management, interpretation and dissemination in proteomics research. Expand
CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection
It is shown that the T-cell antigen receptor and the CD1c protein mediate recognition of an evolutionarily conserved family of isoprenoid glycolipids whose members include essential components of protein glycosylation and cell-wall synthesis pathways. Expand
Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study.
The results of this multi-institutional study indicate that MS-based analysis appears as the efficient method for identification and quantitation of oligosaccharides in glycomic studies and endorse the power of MS for glycopeptide characterization with high sensitivity in proteomic programs. Expand
Electron capture dissociation and infrared multiphoton dissociation MS/MS of an N-glycosylated tryptic peptic to yield complementary sequence information.
The applicability of ECD for glycopeptide analysis to N-glycosylated peptides and to peptides containing branched, highly substituted glycans is extended and the two types of spectra, obtained with the same instrument, provide complementary structural information about the glycopePTide. Expand