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Sarcopenia: revised European consensus on definition and diagnosis
TLDR
An emphasis is placed on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarc Openia diagnosis, and provides clear cut-off points for measurements of variables that identify and characterise sarc openia. Expand
Hip fractures in the elderly: A world-wide projection
TLDR
The results suggest that osteoporosis will truly become a global problem over the next half century, and that preventive strategies will be required in parts of the world where they are not currently felt to be necessary. Expand
Osteoporosis in the European Union: medical management, epidemiology and economic burden
TLDR
In spite of the high social and economic cost of osteoporosis, a substantial treatment gap and projected increase of the economic burden driven by the aging populations, the use of pharmacological interventions to prevent fractures has decreased in recent years, suggesting that a change in healthcare policy is warranted. Expand
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
TLDR
Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity. Expand
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
TLDR
It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes. Expand
Effect of in utero and early-life conditions on adult health and disease.
TLDR
Evidence from several disciplines is synthesized to support the contention that environmental factors acting during development should be accorded greater weight in models of disease causation. Expand
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
SummaryGuidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis.IntroductionThe International OsteoporosisExpand
Risk of new vertebral fracture in the year following a fracture.
TLDR
The data indicate that women who develop a vertebral fracture are at substantial risk for additional fracture within the next year, and the presence of prevalent vertebral fractures increases this risk. Expand
Common variants near MC4R are associated with fat mass, weight and risk of obesity
TLDR
It is established that common variants near MC4R influence fat mass, weight and obesity risk at the population level and reinforce the need for large-scale data integration to identify variants influencing continuous biomedical traits. Expand
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Summary Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis. Introduction The International OsteoporosisExpand
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