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Microrna expression distinguishes between germinal center B cell‐like and activated B cell‐like subtypes of diffuse large B cell lymphoma
Diffuse large B cell lymphoma (DLBCL) is an aggressive malignancy that accounts for nearly 40% of all lymphoid tumors. This heterogeneous disease can be divided into germinal center B cell‐like (GCB)Expand
Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases*
The presented data offer a model for the quaternary assembly of this E3 class that supports the bivalent capture of Nrf2 and reveals potential new sites for E3 inhibitor design. Expand
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase.
It is reported that recombinant PHF8 is an Fe(II) and 2-oxoglutarate-dependent N(epsilon)-methyl lysine demethylase, which acts on histone substrates, and is selective in vitro for N( epsilon-di- and mono-methylatedLysine residues and does not accept trimethyl substrates. Expand
High-throughput production of human proteins for crystallization: The SGC experience
The methods utilized in the Structural Genomics Consortium in Oxford are described, resulting in successful purification of 48% of human proteins attempted; of those, the structures of ∼40% were solved by X-ray crystallography. Expand
Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev
The first indication of a redox-dependent regulatory mechanism that may control the activity of this subset of oncogenic Ets transcription factors is presented. Expand
A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation
It is shown that the β-hairpin is required for the DNA unwinding and Holliday junction (HJ) resolution activity of full-length RECQ1, confirming that it represents an important determinant for the distinct substrate specificity of the five human RecQ helicases. Expand
Structural insights into the function of ZRANB3 in replication stress response
It is proposed that PCNA and ATP-dependency serve as a multi-layered regulatory mechanism that modulates ZRANB3 activity at replication forks and this data provides important structural insights into the PCNA-APIM interaction, and reveals unexpected similarities between the PIP box and the APIM motif. Expand
MicroRNA expression in lymphocyte development and malignancy
Microarray analysis was used to look at microRNA expression in a wide range of hematological cell lines including all major types of B- and T-cell lymphoma, nonmalignant lymphoproliferative disorder, persistent polyclonal B- cell lymphocytosis (PPBL) and acute myeloid leukemia (AML). Expand
Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization.
It is concluded that mutations in MEGF8 cause a Carpenter syndrome subtype frequently associated with defective left-right patterning, probably through perturbation of signaling by hedgehog and nodal family members. Expand
Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway
A model for DNA binding to thePolθ helicase domain in the context of the Polθ tetramer is proposed, which suggests a role for the helicasedomain in strand annealing of DNA templates for subsequent processing by the polymerase domain. Expand