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Enzymatic degradation of glycosaminoglycans.
Glycosaminoglycans (GAGs) play an intricate role in the extracellular matrix (ECM), not only as soluble components and polyelectrolytes, but also by specific interactions with growth factors andExpand
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Development of Sustainable Bioprocesses: Modeling and Assessment
Preface. Acknowledgements. List of Contributors. Part I: Theoretical Introduction. 1. Introduction. 1.1. Bioprocesses. 1.2. Modeling and Assessment in Process Development. 2. Development ofExpand
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Polysaccharide lyases
Polysaccharide lyases (or eliminases) are a class of enzymes (EC 4.2.2.-) that act to cleave certain activated glycosidic linkages present in acidic polysaccharides. These enzymes act through anExpand
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Heparan Sulfate Mediates bFGF Transport through Basement Membrane by Diffusion with Rapid Reversible Binding*
Basic fibroblast growth factor (bFGF) is a pluripotent cytokine with a wide range of target cells. Heparan sulfate binds bFGF, and this interaction has been demonstrated to protect bFGF againstExpand
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Preparative purification of supercoiled plasmid DNA using anion-exchange chromatography.
Large scale manufacturing of gene vectors such as plasmid DNA is an important issue in gene therapy. Anion-exchange chromatography is fundamental in the downstream processing of plasmids both as aExpand
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Model of oxygen transport limitations in hollow fiber bioreactors
Axial and radial oxygen depletion are believed to be critical scale‐limiting factors in the design of cell culture hollow fiber bioreactors. A mathematical analysis of oxygen depletion has beenExpand
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End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation.
A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated manyExpand
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Fermentation and Enzyme Technology
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A review on the continuous blending of powders
This review traces the underlying theory and practice of continuous powder blending to provide a foundation for its development. Apart from reviewing the experimental studies reported in literature,Expand
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Large-scale production of pharmaceutical-grade plasmid DNA for gene therapy: problems and bottlenecks.
Gene therapy is a promising process for the prevention, treatment and cure of diseases such as cancer, acquired immunodeficiency syndrome (AIDS) and cystic fibrosis. One of the methods used toExpand
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