Disposition of Glucosinolates and Sulforaphane in Humans After Ingestion of Steamed and Fresh Broccoli
- C. Conaway, Serkadis M. Getahun, F. Chung
- Medicine, ChemistryNutrition and Cancer
- 1 November 2000
Results of this study indicate that the bioavailability of ITCs from fresh broccoli is approximately three times greater than that from cooked broccoli, in which myrosinase is inactivated.
Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans.
- C. Conaway, Yang-ming Yang, F. Chung
- Biology, ChemistryCurrent drug metabolism
- 31 May 2002
The goal of this review is to provide a mechanistic understanding for the biological activities of ITCs and to relate the metabolism of I TCs to their action as chemopreventive agents.
Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate.
- F. Chung, C. Conaway, C. Rao, B. Reddy
- Biology, MedicineCarcinogenesis
- 1 December 2000
Findings provide important laboratory evidence for a potential role of SFN and PEITC in the protection against colon cancer.
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
- C. Conaway, Chung-Xiou Wang, F. Chung
- Chemistry, MedicineCancer Research
- 15 September 2005
The chemopreventive activity of phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates during progression of lung adenomas to malignant tumors was investigated in A/J mice and significant reduction in proliferating cell nuclear antigen and induction of apoptosis was indicated.
Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells.
- J. Chiao, F. Chung, R. Kancherla, T. Ahmed, A. Mittelman, C. Conaway
- Biology, ChemistryInternational Journal of Oncology
- 1 March 2002
SFN and its metabolite SFN-NAC have similar activities to induce growth arrest and apoptosis, indicating that the effects of SFN are maintained through the metabolic processes.
Urinary isothiocyanate levels, brassica, and human breast cancer.
Brassica vegetable consumption (e.g., Chinese cabbage) provides isothiocyanates (ITC) and other glucosinolate derivatives capable of inducing Phase II enzymes [e.g., glutathione S-transferases…
Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats.
- C. Conaway, D. Jiao, T. Kohri, L. Liebes, F. Chung
- Biology, ChemistryDrug Metabolism And Disposition
- 1999
Higher effective doses of PHITC in the lungs and other organs may be the basis, in part, for its greater potency as a chemopreventive agent.
High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate.
- L. Liebes, C. Conaway, F. Chung
- Biology, ChemistryAnalytical Biochemistry
- 15 April 2001
The applicability of the methodology to pharmacokinetic studies of PEITC in humans is demonstrated and linearity and reproducibility with human plasma over a range of 49-3003 nM phenethyl isothiocyanate (PEITC) are shown.
Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane.
- E. Fiala, C. Conaway, J. Mathis
- Biology, MedicineCancer Research
- 15 October 1989
These findings are consistent with a mechanism of hepatocarcinogenicity of 2-NP based on damage to nucleic acids from the intracellular generation of reactive forms of oxygen and/or the 2- NP free radical.
Synthesis of (-)-[4-3H]epigallocatechin gallate and its metabolic fate in rats after intravenous administration.
- T. Kohri, F. Nanjo, F. Chung
- Medicine, ChemistryJournal of Agricultural and Food Chemistry
- 13 January 2001
Results showed that bile was the major excretion route of EGCg, and radioactivity levels of bile and urine were quantified after intravenous administration of [4-(3)H]EGCg to bile-duct-cannulated rats.
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