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Disposition of Glucosinolates and Sulforaphane in Humans After Ingestion of Steamed and Fresh Broccoli
Results of this study indicate that the bioavailability of ITCs from fresh broccoli is approximately three times greater than that from cooked broccoli, in which myrosinase is inactivated.
Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans.
The goal of this review is to provide a mechanistic understanding for the biological activities of ITCs and to relate the metabolism of I TCs to their action as chemopreventive agents.
Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate.
Findings provide important laboratory evidence for a potential role of SFN and PEITC in the protection against colon cancer.
Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells.
SFN and its metabolite SFN-NAC have similar activities to induce growth arrest and apoptosis, indicating that the effects of SFN are maintained through the metabolic processes.
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.
The chemopreventive activity of phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates during progression of lung adenomas to malignant tumors was investigated in A/J mice and significant reduction in proliferating cell nuclear antigen and induction of apoptosis was indicated.
High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate.
The applicability of the methodology to pharmacokinetic studies of PEITC in humans is demonstrated and linearity and reproducibility with human plasma over a range of 49-3003 nM phenethyl isothiocyanate (PEITC) are shown.
Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China.
  • J. Fowke, X. Shu, +6 authors Wei Zheng
  • Biology, Medicine
    Cancer epidemiology, biomarkers & prevention : a…
  • 1 December 2003
A single urinary ITC measure, in conjunction with markers of Phase II enzyme activity, provides a complementary measure of habitual Brassica intake among Shanghai women.
Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane.
These findings are consistent with a mechanism of hepatocarcinogenicity of 2-NP based on damage to nucleic acids from the intracellular generation of reactive forms of oxygen and/or the 2- NP free radical.
Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention.
Exposure of human androgen-independent DU-145 prostate cancer cells to SFN resulted in the inhibition of growth and tumorigenesis, as revealed by a reduction in cell density, DNA synthesis, and clonogenesis.
Synthesis of (-)-[4-3H]epigallocatechin gallate and its metabolic fate in rats after intravenous administration.
Results showed that bile was the major excretion route of EGCg, and radioactivity levels of bile and urine were quantified after intravenous administration of [4-(3)H]EGCg to bile-duct-cannulated rats.