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Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization.
This study shows that RPE cells express MCP, a cytokine involved with macrophage recruitment, and that macrophages express TF in CNV, thus perpetuating angiogenesis. Expand
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo.
It is reported that mice with melanocyte-specific expression of activated H-rasG12V on an ink4a-deficient background develop spontaneous cutaneous melanomas after a short latency and with high penetrance, and this mouse model affords a system in which to identify and analyze pathways involved in tumor progression against the backdrop of genetic alterations encountered in human melanomas. Expand
Pseudopalisades in Glioblastoma Are Hypoxic, Express Extracellular Matrix Proteases, and Are Formed by an Actively Migrating Cell Population
The findings that pseudopalisading cells are 5–50% less proliferative and 6–20 times more apoptotic than adjacent astrocytoma, indicating that cell accumulation does not result from increased proliferation or resistance to apoptosis, suggest that Pseudopalisades cells are migrating at the periphery of a hypoxic center. Expand
Distribution of Cytokeratins and Vimentin in Adult Renal Neoplasms and Normal Renal Tissue: Potential Utility of a Cytokeratin Antibody Panel in the Differential Diagnosis of Renal Tumors
The purpose of this study was to determine the diagnostic utility of cytokeratin (CK) subtype expression pattern in a wide range of adult RENs and found that CK expression patterns may be useful in several differential diagnostic settings. Expand
Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers.
The expression patterns of 7075 genes were analyzed in four conventional (clear cell) renal cell carcinomas (RCC), one chromophobe RCC, and two oncocytomas using cDNA microarrays. Expression profilesExpand
Discriminatory Immunohistochemical Staining of Urothelial Carcinoma in Situ and Non-neoplastic Urothelium: An Analysis of Cytokeratin 20, p53, and CD44 Antigens
  • J. McKenney, Sangeeta Desai, C. Cohen, Mahul B. Amin
  • Biology, Medicine
  • The American journal of surgical pathology
  • 1 August 2001
Abnormal expression of CK20 (increased), p53 ( increased), and CD44 (decreased) in urothelial CIS, and increased expression of CD44 in reactive atypia allows more confident distinction of urothalial CIS from non-neoplastic urothelia atypias. Expand
Immunohistochemical Analysis of Mucinous Tubular and Spindle Cell Carcinoma and Papillary Renal Cell Carcinoma of the Kidney: Significant Immunophenotypic Overlap Warrants Diagnostic Caution
In tumors with predominant compact tubular growth and focal papillary architectures, careful attention to the presence of a low-grade spindle cell population may be helpful in the distinction of mucinous tubular and spindlecell carcinoma, as the key immunohistochemical stains for papillary renal cell carcinoma are also expressed in this subtype of renal cell cancer. Expand
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
It is demonstrated that Akt was associated with malignant transformation of melanoma through at least 2 mechanisms, and may stabilize cells with extensive mitochondrial DNA mutation, which can generate ROS, and can induce expression of the ROS-generating enzyme NOX4. Expand
Reactive oxygen generated by Nox1 triggers the angiogenic switch
It is shown that Nox1 is a potent trigger of the angiogenic switch, increasing the vascularity of tumors and inducing molecular markers of angiogenesis. Expand
Molecular classification of renal tumors by gene expression profiling.
Renal tumor subtypes were classified by distinct gene expression profiles, illustrating tumor pathobiology and translating into novel molecular bioassays using fixed tissue. Expand