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Human cytomegalovirus infection and expression in human malignant glioma.
Malignant gliomas are the most common primary brain tumors in adults, have no known etiology, and are generally rapidly fatal despite current therapies. Human cytomegalovirus (HCMV) is… Expand
The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
AbstractQuestionShould patients with newly-diagnosed metastatic brain tumors undergo stereotactic radiosurgery (SRS) compared with other treatment modalities? Target population These… Expand
Conserved cell types with divergent features in human versus mouse cortex
Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-sequencing… Expand
Expression of nitric oxide synthase in human central nervous system tumors.
- C. Cobbs, J. Brenman, K. Aldape, D. Bredt, M. Israel
- Biology, Medicine
- Cancer research
- 15 February 1995
The nitric oxide synthases (NOS) are a family of related enzymes which regulate the production of NO, a free radical gas implicated in a wide variety of biological processes. Vasodilation and… Expand
The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline
AbstractQuestionShould patients with newly-diagnosed metastatic brain tumors undergo open surgical resection versus whole brain radiation therapy (WBRT) and/or other treatment modalities such as… Expand
Consensus on the role of human cytomegalovirus in glioblastoma.
The human cytomegalovirus (HCMV) and glioma symposium was convened on April 17, 2011 in Washington, DC, and was attended by oncologists and virologists involved in studying the relationship between… Expand
Platelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus that can cause life-threatening disease in the fetus and the immunocompromised host. Upon attachment to the cell, the virus induces… Expand
Is HCMV a tumor promoter?
Human cytomegalovirus (HCMV) is a beta-herpesvirus that causes persistent infection in humans and can cause severe disease in fetuses and immunocompromised individuals. Although HCMV is not currently… Expand
An anatomic transcriptional atlas of human glioblastoma
Anatomically correct tumor genomics Glioblastoma is the most lethal form of human brain cancer. The genomic alterations and gene expression profiles characterizing this tumor type have been widely… Expand
Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer
- L. Harkins, Andrea L. Volk, M. Samanta, Ivan Mikolaenko, C. Cobbs
- Medicine, Biology
- The Lancet
- 16 November 2002
BACKGROUND Colorectal cancer is the second most frequent cause of death from cancer in the USA, and most tumours arise sporadically with no clear cause or genetic predisposition. Human… Expand