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Quality-of-life impairment in depressive and anxiety disorders.
TLDR
Subjects with affective or anxiety disorders who enter clinical trials have significant quality-of-life impairment, although the degree of dysfunction varies, and diagnostic-specific symptom measures explained only a small proportion of the variance in quality of life.
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Sertraline treatment of major depression in patients with acute MI or unstable angina
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Behavior therapy for obsessive-compulsive disorder guided by a computer or by a clinician compared with relaxation as a control.
TLDR
Computer-guided behavior therapy can be a helpful first step in treating patients with OCD when clinician-guidedbehavior therapy is unavailable, and systematic relaxation was ineffective.
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Comparison of sertraline and nortriptyline in the treatment of major depressive disorder in late life.
TLDR
Primary efficacy measures showed sertraline and nortriptyline to be similarly effective and secondary efficacy measures (posttreatment measures of cognitive function, memory, and quality of life) revealed a significant advantage for sERTraline treatment.
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A double-blind comparison of sertraline and fluoxetine in depressed elderly outpatients.
TLDR
Data indicate that both drugs are effective antidepressants for the treatment of depressed elderly outpatients and differences in cognitive performance effects deserve further investigation.
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Efficacy of sertraline in a 12-week trial for generalized anxiety disorder.
TLDR
Sertraline appears to be efficacious and well tolerated in the treatment of generalized anxiety disorder.
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The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive disorder
TLDR
It is suggested that genetic variation in the serotonin transporter gene effects the response time to sertraline and provides complementing evidence to previous reports that this polymorphism affects responseTime to other SSRIs.
View on Springer
Does antidepressant therapy improve cognition in elderly depressed patients?
TLDR
Acute improvement in depression is associated with cognitive improvement as measured by the Shopping List Task and the Digit Symbol Substitution Test, which quantifies short-term and long-term memory storage and retrieval.
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Efficacy of sertraline in severe generalized social anxiety disorder: results of a double-blind, placebo-controlled study.
TLDR
The results of the current study confirm the efficacy and tolerability of sertraline in the treatment of severe social anxiety disorder.
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An 8-week multicenter, parallel-group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression.
TLDR
Sertraline was effective and well tolerated by older adults with major depression, although the drug-placebo difference was not large in this 8-week trial.
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