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Physiological action of progesterone in target tissues.
I. Introduction II. Synthesis and Secretion of Progesterone III. The Progesterone Receptor A. PR expression and regulation IV. Progesterone Regulation of Gene Expression in the Uterus, Ovary, and… Expand
Progesterone induces adult mammary stem cell expansion
Reproductive history is the strongest risk factor for breast cancer after age, genetics and breast density. Increased breast cancer risk is entwined with a greater number of ovarian hormone-dependent… Expand
Association analysis identifies 65 new breast cancer risk loci
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast… Expand
Loss of Co-ordinate Expression of Progesterone Receptors A and B is an Early Event in Breast Carcinogenesis
- P. Mote, S. Bartow, N. Tran, C. Clarke
- Medicine, Biology
- Breast Cancer Research and Treatment
- 1 March 2002
Progesterone receptor (PR) mediates the effects of progesterone in mammary tissues and plays a crucial role in normal breast development and in breast cancer. PR proteins are expressed as two… Expand
Progestin regulation of cellular proliferation.
I. Introduction THE control of cellular proliferation is known to involve a delicate balance between the effects of different regulatory molecules including hormones and growth factors which provide,… Expand
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
- N. Mavaddat, P. Pharoah, +209 authors M. García‐Closas
- Journal of the National Cancer Institute
- 2 April 2015
Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive… Expand
Colocalization of progesterone receptors A and B by dual immunofluorescent histochemistry in human endometrium during the menstrual cycle.
- P. Mote, R. Balleine, E. McGowan, C. Clarke
- Medicine, Biology
- The Journal of clinical endocrinology and…
- 1 August 1999
The human progesterone receptor (PR) is expressed as two isoforms, PRA and PRB, that function as ligand-activated transcription factors. In vitro studies suggest that the isoforms differ functionally… Expand
Imatinib Disposition and ABCB1 (MDR1, P‐Glycoprotein) Genotype
The aim of this study was to explore the impact of individual variation in drug elimination on imatinib disposition. Twenty‐two patients with gastrointestinal stromal tumor or chronic myeloid… Expand
Expression and regulation of retinoic acid receptors in human breast cancer cells.
- S. Roman, C. Clarke, R. Hall, I. Alexander, R. Sutherland
- Biology, Medicine
- Cancer research
- 15 April 1992
Retinoic acid is known to inhibit mammary carcinogenesis in rodents and to inhibit proliferation and steroid hormone receptor gene expression in human breast cancer cells. Since these effects are… Expand
Characterization of progesterone receptor A and B expression in human breast cancer.
The human progesterone receptor (PR) is a ligand-activated nuclear transcription factor that mediates progesterone action in target tissues. Two PR proteins, PR-A (M(r) 81,000-83,000) and PR-B (M(r)… Expand