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In Vitro Activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with Defined Macrolide Resistance Mechanisms

CEM-101 had low MICs as well as low potential for the selection of resistant mutants, independent of bacterial species or resistance phenotypes in pneumococci and S. pyogenes.
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Activity of Telavancin against Staphylococci and Enterococci Determined by MIC and Resistance Selection Studies

Telavancin demonstrated potent activity against all vancomycin-susceptible isolates as well as against heterogeneously VISA and VISA resistance phenotypes, and two enterococci developed resistance to daptomycin, and one developing resistance to linezolid.
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Single- and Multistep Resistance Selection Studies on the Activity of Retapamulin Compared to Other Agents against Staphylococcus aureus and Streptococcus pyogenes

ABSTRACT Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all…
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Activities of Ceftobiprole, a Novel Broad-Spectrum Cephalosporin, against Haemophilus influenzae and Moraxella catarrhalis

Time-kill analyses showed that ceftobiprole, ceftriaxone, cefpodoxime, amoxicillin-clavulanate, azithromycin, telithromyzin, and moxifloxacin were bactericidal at 2× MIC by 24 h against all 10 H. influenzae strains surveyed.
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In Vitro Selection of Resistance in Haemophilus influenzae by Amoxicillin-Clavulanate, Cefpodoxime, Cefprozil, Azithromycin, and Clarithromycin

Ability to select resistant mutants of Haemophilus influenzae were tested by multistep and single-step methodologies and azithromycin had the highest mutation rates, while amoxicillin-clavulanate had the lowest.
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Antipneumococcal activity of AZD2563, a new oxazolidinone, compared with nine other agents.

The in vitro activity of AZD2563, a new oxazolidinone, was compared with that of linezolid, vancomycin, quinupristin/dalfopristin, amoxicillin, levofloxacin, penicillin, erythromycin, azithromycin…
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Antipneumococcal Activity of Ceftobiprole, a Novel Broad-Spectrum Cephalosporin

Prolonged serial passage in the presence of subinhibitory concentrations of ceftobiprole failed to yield mutants with high MICs towards this Staphylococcus aureus cephalosporin, and single-passage selection showed very low frequencies of spontaneous mutants with breakthroughMICs towards ceftOBiprole.
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Activity of cefditoren against respiratory pathogens.

Multistep studies of cefditoren, co-amoxiclav and cefprozil did not select for resistant mutants after 50 subcultures, compared with cefuroxime and azithromycin, where resistant mutants were selected in two and nine strains, respectively.
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Antipneumococcal Activities of Levofloxacin and Clarithromycin as Determined by Agar Dilution, Microdilution, E-Test, and Disk Diffusion Methodologies

ABSTRACT The activities of levofloxacin and clarithromycin against 199 penicillin- and macrolide-susceptible and -resistant pneumococci were tested by agar and microdilution methods in air and by…
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Multistep Resistance Development Studies of Ceftaroline in Gram-Positive and -Negative Bacteria

The potential for ceftaroline and comparator antibiotics to select for clones of Streptococcus pneumoniae, StrePTococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniaes, Staphylococcus aureus, and Enterococcus faecalis with elevated MICs was evaluated.
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