C. Clérici

Publications100
h-index34
Citations4,452
Highly Influential Citations181
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Lung epithelial fluid transport and the resolution of pulmonary edema.
TLDR
There is convincing evidence that active sodium and chloride transporters are expressed in the distal lung epithelium and are responsible for the ability of the lung to remove alveolar fluid at the time of birth as well as in the mature lung when pathological conditions lead to the development of pulmonary edema. Expand
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.
TLDR
Data indicate that, during prolonged hypoxia, HIF-alpha proteins negatively regulate Hif-1alpha expression through an increase in aHIF and destabilization of HIF -1alpha mRNA, likely conveys target gene specificity. Expand
Nutritional Consequences of Adjustable Gastric Banding and Gastric Bypass: A 1-year Prospective Study
TLDR
Severe nutritional deficits can be avoided after bariatric surgery if patients are systematically supplemented with multivitamin and carefully monitored, however, specific care is required to avoid iron and vitamin B12 deficiencies, anemia, and protein malnutrition. Expand
Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells
TLDR
Data indicate that, during prolonged hypoxia, HIF-α proteins negatively regulate Hif-1α expression through an increase in aHIF and destabilization of HIF/2α mRNA, which likely conveys target gene specificity. Expand
Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells.
TLDR
It is concluded that hypoxia induced a downregulation of expression and activity of epithelial Na channels and Na,K-ATPase in alveolar cells and this was associated with complete functional recovery. Expand
Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment.
TLDR
The dramatic increase of ALC with beta(2)-agonist therapy indicates that the decrease of transepithelial Na and fluid transport during hypoxia is rapidly reversible, a finding of major clinical significance. Expand
Comparison of Nutritional Consequences of Conventional Therapy of Obesity, Adjustable Gastric Banding, and Gastric Bypass
TLDR
RYGBP is more efficient than AGB in correcting obesity, but this operation is associated with a higher frequency of nutritional deficits that should be carefully monitored. Expand
Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo.
TLDR
Findings suggest that release of VEGF synthesized by AEC may target not only endothelial cells but also other alveolar cells, including macrophages and epithelial cells, as well as bronchoalveolar lavage fluid. Expand
Cardiovascular remodelling and extracellular fluid excess in early stages of chronic kidney disease.
TLDR
This study shows that CV remodelling and ECF excess occurred at a very early stage of CKD, indicating that early therapeutic control of ECF may reduce CV events in CKD patients. Expand
The Impact of Bariatric Surgery on Comorbidities and Medication Use Among Obese Patients
TLDR
Bariatric surgery was associated with significant reductions in reported claims for short- and long-term health outcomes and reduced medication use for major disease categories. Expand
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