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Lanosterol reverses protein aggregation in cataracts
The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and refractive index. Any disruption of intra-… Expand
Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial
MERTK is an essential component of the signaling network that controls phagocytosis in retinal pigment epithelium (RPE), the loss of which results in photoreceptor degeneration. Previous… Expand
Cyclic strain in human carotid bifurcation and its potential correlation to atherogenesis: Idealized and anatomically-realistic models
Various mechanical phenomena are thought to contribute to the pathogenesis of atherosclerosis. Most finite-element analyses of arterial-wall mechanics to date have focused on the quantification of… Expand
Lens regeneration using endogenous stem cells with gain of visual function
The repair and regeneration of tissues using endogenous stem cells represents an ultimate goal in regenerative medicine. To our knowledge, human lens regeneration has not yet been demonstrated.… Expand
Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma.
AIM To describe the significant over-expression of fibroblast growth factor receptor 3 (FGFR3), which is a signal transduction and cell proliferation related gene in hepatocellular carcinoma (HCC).… Expand
Glutamatergic Projections to the Cochlear Nucleus are Redistributed in Tinnitus
Tinnitus alters auditory-somatosensory plasticity in the cochlear nucleus (CN). Correspondingly, bimodal auditory-somatosensory stimulation treatment attenuates tinnitus, both in animals and humans… Expand
Protocols for Developing Novel Chikungunya Virus DNA Vaccines.
- C. Chung, K. Ugen, N. Sardesai, D. Weiner, K. Muthumani
- Biology, Medicine
- Methods in molecular biology
To date, there have been several million infections by the Chikungunya virus (CHIKV), a mosquito-transmitted emerging pathogen that is considered to be taxonomically an Old World RNA virus. Although… Expand
Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma.
- W. Qiu, Bingsen Zhou, +6 authors Y. Yen
- Biology, Medicine
- The American journal of pathology
- 1 November 2004
Growth arrest DNA damage-inducible gene 45 beta (GADD45beta) has been known to regulate cell growth, apoptotic cell death, and cellular response to DNA damage. Down-regulation of GADD45beta has been… Expand
Corrigendum: Lanosterol reverses protein aggregation in cataracts
This corrects the article DOI: 10.1038/nature14650
Bovine Serum Albumin Enhances Silver Nanoparticle Dissolution Kinetics in a Size- and Concentration-Dependent Manner.
- Daniel J Boehmler, Zachary J O'Dell, C. Chung, Kathryn R. Riley
- Chemistry, Medicine
- Langmuir : the ACS journal of surfaces and…
- 5 January 2020
The dissolution of silver nanoparticles (AgNPs) to release Ag(I)(aq) is an important mechanism in potentiating AgNP cytotoxicity and imparting their antibacterial properties. However, AgNPs can… Expand