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Antidepressant-like effect of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in mice forced swim test
The present study aimed to examine the antidepressant-like effect of the neurosteroid 3α-hydroxy-5α-pregnan-20-one (3α, 5α THP) using the forced swim test in mice. Intracerebroventricular (ICV, 1 or… Expand
Behavioral action of ethanol in Porsolt’s forced swim test: modulation by 3alpha-hydroxy-5alpha-pregnan-20-one
Ethanol is known to increase cortical and plasma content of GABAergic neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP) which is responsible for some of its behavioral and… Expand
Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test.
The present study aimed to examine the antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha, 5alpha THP) using the forced swim test in mice.… Expand
Anticonvulsive activity of Butea monosperma flowers in laboratory animals
- V. Kasture, S. Kasture, C. Chopde
- Medicine, Psychology
- Pharmacology Biochemistry and Behavior
- 1 July 2002
The bioassay-guided fractionation of dried flowers of Butea monosperma (BM) was carried out to isolate the active principle responsible for its anticonvulsant activity. The petroleum ether extract… Expand
Anxiolytic and anticonvulsive activity of Sesbania grandiflora leaves in experimental animals
Various parts of Sesbania grandiflora have been used in the Indian system of medicine, in particular, the leaves of S. grandiflora are used in Ayurveda for the treatment of epileptic fits. In the… Expand
Involvement of alpha-melanocyte stimulating hormone (α-MSH) in differential ethanol exposure and withdrawal related depression in rat: Neuroanatomical–behavioral correlates
- D. M. Kokare, P. Singru, Manoj P. Dandekar, C. Chopde, N. Subhedar
- Biology, Medicine
- Brain Research
- 24 June 2008
We investigated the involvement of alpha-melanocyte stimulating hormone (alpha-MSH) following acute, chronic and withdrawal treatments of ethanol with reference to depression. The degree of… Expand
Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.
The ethanolic extracts of leaves of Albizzia lebbeck and flowers of Hibiscus rosa sinesis and the petroleum ether extract of flowers of Butea monosperma exhibited anticonvulsant activity. The… Expand
Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice.
The present study demonstrated the antidepressant-like effect of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha, 5alpha THP) in mouse forced swim test of depression and its modulation by… Expand
Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine
- B. Taksande, N. Kotagale, S. J. Tripathi, R. Ugale, C. Chopde
- Medicine, Psychology
- 1 September 2009
Recent findings demonstrated the dysregulation of imidazoline receptor binding sites in major depression and their normalization by chronic treatment with antidepressants including selective… Expand
Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in mice
The present study demonstrated the antidepressant-like effect of neurosteroid 3α-hydroxy-5α-pregnan-20-one (3α, 5α THP) in mouse forced swim test of depression and its modulation by different… Expand