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Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum.
The roots of Eurycoma longifolia Jack have been used as traditional medicine to treat malaria. A systematic bioactivity-guided fractionation of this plant was conducted involving the determination ofExpand
Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds.
TLDR
The reduction of blood glucose concentration by both bruceines was comparable to glibenclamide and they might act as an insulin secretagogue and the acute toxicity of the compounds was evaluated in mice. Expand
High performance liquid chromatography in phytochemical analysis of Eurycoma longifolia.
TLDR
An analytical method using HPLC with UV detection was developed to investigate the quassinoid content of Eurycoma longifolia Jack (Simaroubaceae) collected from various sources, finding 1 had the highest concentration, being about 16.8-39.6 fold higher than the other quassinoids 2, 3, 5, 7 but 145.3 folds higher than 4 which showed the lowest concentration. Expand
The cytotoxicity and chemical constituents of the hexane fraction of Typhonium flagelliforme (Araceace).
TLDR
The plant, Typhonium flagelliforme (Araceae), commonly known as the "rodent tuber" in Malaysia, is often used as an essential ingredient of herbal remedies for alternative cancer therapies and showed weak cytotoxic activity against in vitro culture on P388 murine leukaemia cells. Expand
Vitexin and isovitexin from the Leaves of Ficus deltoidea with in-vivo α-glucosidase inhibition.
TLDR
Both the C-glycosyl bioflavonoids, namely, vitexin and isovitexIn exhibited in vivo α-glucosidase inhibition. Expand
Vasorelaxant activity of cyclic peptide, cyclosquamosin B, from Annona squamosa.
TLDR
Results showed that the vasorelaxant effect by cyclosquamosin B might be attributed mainly to inhibition of calcium influx from extracellular space through voltage-dependent calcium channels. Expand
The toxicity of some quassinoids from Eurycoma longifolia.
TLDR
Toxicity-guided chromatographic fractionation of the n-butanol fraction identified eurycomanone as the most toxic component and an oxymethylene bridge connecting C-8 and C-11 of ring C contributed to increased toxicity. Expand
Dichotomins J and K, vasodilator cyclic peptides from Stellaria dichotoma.
Two new cyclic peptides, dichotomins J (1) and K (2), have been isolated from the roots of Stellaria dichotoma, and their structures were elucidated by chemical degradation and extensive 2D NMRExpand
Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase.
TLDR
Three new Lycopodium alkaloid alkaloids, carinatumins A-C (1-3), have been isolated from the club moss Lycopododium carInatum and exhibited a potent inhibitory activity against acetylcholinesterase. Expand
High performance liquid chromatography analysis of canthinone alkaloids from Eurycoma longifolia.
TLDR
A reversed phase-high performance liquid chromatography method with a photodiode array detector was developed for the simultaneous determination of three major alkaloids, 3-methylcanthin-5,6-dione and its 9-methoxy analogue in Eurycoma longifolia Jack. Expand
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