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Membrane-bound α-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form*
α-Synuclein exists as at least two structural isoforms: a helix-rich, membrane-bound form and a disordered, cytosolic form. Here, we investigated the role of membrane-bound α-synuclein in theExpand
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Preparation of poly(DL-lactide-co-glycolide) microspheres encapsulating all-trans retinoic acid.
Poly(DL-lactide-co-glycolide) (PLGA) microspheres containing all-trans retinoic acid (atRA) were prepared by o/w solvent evaporation method and various preparation parameters, such as poly(vinylExpand
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Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas
Gastric carcinogenesis involves multiple genetic and epigenetic alterations. Epigenetic silencing of tumor-related genes due to CpG island methylation (CIM) has been recently reported in gastricExpand
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Analysis of Fine Needle Aspiration Cytology of the Breast
OBJECTIVE To evaluate the accuracy of fine needle aspiration (FNA) cytology of the breast and to ascertain its usefulness. STUDY DESIGN The authors reviewed 1,297 cases of FNA cytology of theExpand
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Renal cell carcinoma in South Korea: a multicenter study.
The incidence of renal cell carcinoma (RCC) in South Korea is steadily becoming similar to that in Western countries. This study summarizes the results of a 3-year multicenter survey of RCC in SouthExpand
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Expression of PTEN in the progression of cervical neoplasia and its relation to tumor behavior and angiogenesis in invasive squamous cell carcinoma
Loss of PTEN expression has been associated with tumor progression and adverse patient outcome. The purpose of this study was to evaluate PTEN expression in the successive steps of progression inExpand
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Quantitative promoter hypermethylation profiles of ductal carcinoma in situ in North American and Korean women: Potential applications for diagnosis
To investigate the diagnostic potential of DNA methylation-based markers in tissuesamples of DCIS, we examined the prevalence and extent of methylation in breastductal carcinoma in situ (DCIS)Expand
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Acquired cystic disease-associated renal cell carcinoma: further characterization of the morphologic and immunopathologic features
Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is a subtype of renal cell carcinoma (RCC) with unique morphologic features found exclusively in the background of end-stage renalExpand
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Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma.
Gastric cancer is common among the world, but genetic mechanisms of gastric carcinogenesis are not well understood. Gastric polypoid adenomas and flat dysplasias are regarded as precursor lesions.Expand
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Brain tumor invasion model system using organotypic brain-slice culture as an alternative to in vivo model
Abstract Purpose. The primary cause of local recurrence and therapeutic failure in the treatment of malignant gliomas is the invasion of tumor cells into the surrounding normal brain. While it isExpand
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