Cytotoxic Hexacyclic Triterpene Acids from Euscaphis japonica.
- Jing-Jy Cheng, Li-Jie Zhang, Hui-ling Cheng, C. Chiou, I-Jung Lee, Y. Kuo
- ChemistryJournal of Natural Products
- 27 September 2010
Six hexacyclic triterpene acids (1-6), named euscaphic acids A-F, and eight known triterPene acid compounds (7-14) were isolated from an ethanolic extract of twigs of Euscaphis japonica and showed significant cytotoxicity against different cancer cell lines.
Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase.
- Chien-Shu Chen, C. Chiou, J. Chern
- Biology, ChemistryJournal of Medicinal Chemistry
- 14 May 2009
These inhibitors with structural novelty may serve as a useful scaffold for the discovery of new HCV NS3 helicase inhibitors and suppressed HCV replication in the HCV replicon cells.
A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study
- K. Tsai, Yi-Chia Huang, Yi-Chang Su
- Medicine, BiologyBiomedicine and Pharmacotherapy
- 19 November 2020
Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein.
- C. Chiou, C. Hu, Pi-Hsin Chen, C. Liao, Yi-Ling Lin, Jaang-Jiun Wang
- BiologyJournal of General Virology
- 1 October 2003
Observations indicate that microtubules and TSG101 associate with NS3, which is incorporated into the JEV-induced structure during JEV replication.
Ultrastructure and localization of E proteins in cultured neuron cells infected with Japanese encephalitis virus.
- J. J. Wang, C. Liao, Y. Chiou, C. Chiou, Y. L. Huang, L. Chen
- BiologyVirology
- 10 November 1997
The interconnections between MVS, rER, and the nuclear envelope and immunogold labeling of E proteins on the MVS provided strong evidence that MVS serve as a reservoir of JEV components during virus assembly.
5-deoxyflavones with cytotoxic activity from Mimosa diplotricha.
- Lie-Chwen Lin, C. Chiou, Jing-Jy Cheng
- ChemistryJournal of Natural Products
- 29 August 2011
Bioassay-guided isolation of Mimosa diplotricha led to the isolation of four new 5-deoxyflavones, diplotrins A-C and diplotasin, together with 12 known flavonoids, flavonolignans, and triterpenoids, which showed the most potent antiproliferative activity.
Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica.
- Li-Jie Zhang, C. Chiou, Y. Kuo
- ChemistryJournal of Natural Products
- 23 April 2010
Biological evaluation showed that all compounds 1-9 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB).
Triterpene Acids from Mesona procumbens Exert Anti-inflammatory Effects on LPS-Stimulated Murine Macrophages by Regulating the MAPK Signaling Pathway.
- Hung-Tse Huang, Chia-Ching Liaw, C. Chiou, Y. Kuo, Kung-Ta Lee
- ChemistryJournal of Agricultural and Food Chemistry
- 26 May 2021
Five new triterpene acids, mesonaic acids A-C (1-3), 2α,3α,19α-trihydroxy-24-nor-4(23),12-oleanadien-28-oic acid (4), and 3α, 19α,22 α-triHydroxy-2-oxo-12-ursen- 28-oIC acid (5) have great potential as NO inhibitors.
Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents.
- C. Chiou, Wei-Chun Lee, Wen-Tai Li
- Biology, ChemistryEuropean journal of medicinal chemistry
- 15 June 2015
Synthesis of Anti‐Microtubule N‐(2‐Arylindol‐7‐yl)benzenesulfonamide Derivatives and Their Antitumor Mechanisms
A series of N-(2-arylindol-7-yl)benzenesulfonamide derivatives and the antitumor mechanism of the most potent compound, N-{2-[(4-Hydroxyphenyl)amino]-3-pyridinyl}-4-methoxybenzenedisulf onamide and its analogues are demonstrated to have potent antitumors activity against drug-resistant tumor cell lines both in vitro and in vivo.
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