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Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
Background— Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting a causal connection.… Expand
Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique.
The focal location of atherosclerosis in the vascular tree is correlated with local variations in shear stress. We developed a method to induce defined variations in shear stress in a straight vessel… Expand
Large variations in absolute wall shear stress levels within one species and between species.
Wall shear stress (WSS), the frictional force between blood and endothelium, is an important determinant of vascular function. It is generally assumed that WSS remains constant at a reference value… Expand
Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines.
We previously found that low shear stress (LSS) induces atherosclerotic plaques in mice with increased lipid and matrix metalloproteinase content and decreased vascular smooth muscle and collagen… Expand
Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction
Background Vascular dysfunction in atherosclerosis and diabetes mellitus, as observed in the aging population of developed societies, is associated with vascular DNA damage and cell senescence. We… Expand
Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening
Abstract Aims More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. The prevalance of diastolic dysfunction is higher in females and… Expand
Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bio-engineered stent in human ex vivo shunt and rabbit denudation model
Aims The Genous™ Bio-engineered R™ stent (GS) aims to promote vascular healing by capture of circulatory endothelial progenitor cells (EPCs) to the surface of the stent struts, resulting in… Expand
PDGF-Induced Migration of Vascular Smooth Muscle Cells Is Inhibited by Heme Oxygenase-1 Via VEGFR2 Upregulation and Subsequent Assembly of Inactive VEGFR2/PDGFR&bgr; Heterodimers
- C. Cheng, R. Haasdijk, +10 authors H. Duckers
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 May 2012
Objective—In cardiovascular regulation, heme oxygenase-1 (HO-1) activity has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation by promoting cell cycle arrest at the G1/S phase.… Expand
Uridine adenosine tetraphosphate is a novel vasodilator in the coronary microcirculation which acts through purinergic P1 but not P2 receptors.
- Z. Zhou, D. Merkus, C. Cheng, H. Duckers, A. H. Jan Danser, D. Duncker
- Chemistry, Medicine
- Pharmacological research
Uridine adenosine tetraphosphate (Up4A) has been identified as an endothelium-derived contracting factor, which acts through purinergic P2X and P2Y receptors. Since the coronary vascular actions of… Expand
Effect of shear stress alteration on atherosclerotic plaque vulnerability in cholesterol-fed rabbits
Previously, we created an experimental murine model for the induction of vulnerable plaque (VP). Although this murine model offers the opportunity to study the different molecular biological pathways… Expand