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Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis.
This review focuses on the process by which a single spermatogonium develops into 256 spermatozoa, one of which will fertilize the ovum, and recaps recent developments in the field.
The Blood-Testis Barrier and Its Implications for Male Contraception
Multiple potential targets are present at the BTB for innovative contraceptive development and for better delivery of drugs to alleviate toxicant-induced reproductive dysfunction in men, as well as critically evaluate findings in the field regarding studies on drug transporters in the testis.
Cadmium-induced testicular injury.
- E. R. Siu, D. Mruk, C. Porto, C. Cheng
- Biology, MedicineToxicology and applied pharmacology
- 1 August 2009
This review critically discusses recent data in the field that have demonstrated the Cd-induced toxicity to the testis is probably the result of interactions of a complex network of causes and sheds lights on potential therapeutic or preventive approaches that can be developed in future studies by blocking or minimizing the destructive effects of Cd to testicular function in men.
Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development.
The physiology and biology of junction dynamics in the testis, in particular how these events affect interactions of Sertoli and germ cells in the seminiferous epithelium behind the blood-testis barrier are discussed.
Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis
- A. Bolino, A. Bolis, +10 authors L. Wrabetz
- Biology, MedicineThe Journal of cell biology
- 22 November 2004
It is proposed that Schwann cell–autonomous loss of Mtmr2–Dlg1 interaction dysregulates membrane homeostasis in the paranodal region, thereby producing outfolding and recurrent loops of myelin.
The Mammalian Blood-Testis Barrier: Its Biology and Regulation.
The biology and regulation of the mammalian blood-testis barrier is reviewed and research areas that should be expanded in future studies are highlighted to create a unique microenvironment for the completion of meiosis and the subsequent development of spermatids into spermatozoa via spermiogenesis.
Claudin and occludin expression and function in the seminiferous epithelium
- C. Morrow, D. Mruk, C. Cheng, R. Hess
- Biology, MedicinePhilosophical Transactions of the Royal Society B…
- 27 May 2010
The characteristics of claudins and occludin; the expression, regulation and function of these integral membrane proteins in the seminiferous epithelium; and how these properties relate to the unique features of BTB are discussed.
Preparation and analysis of isogenic mutants in the transferrin receptor protein genes, tbpA and tbpB, from Neisseria meningitidis
Isogenic mutants constructed in the tbpA and tbpB genes from Neisseria meningitidis strain B16B6 demonstrated a reduced transferrin binding activity in intact cells and total membranes but were incapable of utilizing transferrin iron for growth.
Antioxidant superoxide dismutase - a review: its function, regulation in the testis, and role in male fertility.
It is suggested that SOD(EX) is an important antioxidant molecule in the testis that is under germ cell regulation and stimulated when human recombinant interleukin-1alpha, a germ cell product, was included into Sertoli cells in vitro.
Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis
Findings in the field regarding several selected CT antigens which may be intimately related to spermatogenesis due to their unusual restricted expression during different discrete events of sperMatogenesis, such as cell cycle progression, meiosis, and spermiogenesis are summarized.