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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor signalling and was the first reportedExpand
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Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.
Two series of lupane-type triterpenoic acid derivatives were synthesized and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells, based on the fact thatExpand
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Solubility characteristics and amino acid composition of the endosperm proteins of one line of Triticale, its durum wheat and rye parent cultivars, and one cultivar of hard red spring wheat wereExpand
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Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.
Tankyrase 1 and 2 have been shown to be redundant, druggable nodes in the Wnt pathway. As such, there has been intense interest in developing agents suitable for modulating the Wnt pathway in vivo byExpand
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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays anExpand
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Isolation and Characterization of Human Plasma Lipid Transfer Proteins
A highly purified protein that facilitates the exchange and net mass transfer of cholesteryl ester (CE), and trlacylglycerol (TG), and the transfer of phosphatldylchollne (PC), between plasmaExpand
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Zhankuic acid F: a new metabolite from a formosan fungus Antrodia cinnamomea.
Zhankuic acid F (1), a new steroid acid, was isolated from the fruit bodies of Antrodia cinnamomea Chang & Chou, sp. nov. (Polyporaceae). The structure of 1 was elucidated by detailed analysis of 1D-Expand
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Intracellular Delivery of a Cytolytic T-Lymphocyte Epitope Peptide by Pertussis Toxin to Major Histocompatibility Complex Class I without Involvement of the Cytosolic Class I Antigen Processing
ABSTRACT A CD8+ cytolytic T-lymphocyte (CTL) response to antigen-presenting cells generally requires intracellular delivery or synthesis of antigens in order to access the major histocompatibilityExpand
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Cyclopeptide alkaloids from Paliurus ramossisimus.
Seven zizyphine A-type cyclopeptide alkaloids were isolated from the roots of Paliurus ramossisimus by the combination of centrifugal partition chromatography and conventional separation methods. TheExpand
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