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Genetic control of individual differences in gene-specific methylation in human brain.
We have observed extensive interindividual differences in DNA methylation of 8590 CpG sites of 6229 genes in 153 human adult cerebellum samples, enriched in CpG island "shores" and at furtherExpand
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Removing Batch Effects in Analysis of Expression Microarray Data: An Evaluation of Six Batch Adjustment Methods
The expression microarray is a frequently used approach to study gene expression on a genome-wide scale. However, the data produced by the thousands of microarray studies published annually areExpand
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Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells.
Adult hepatic progenitor (oval) cells are facultative stem cells in liver, which participate in a range of human liver diseases, including hepatocellular carcinoma (HCC). However, the molecularExpand
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Using pseudo-amino acid composition and support vector machine to predict protein structural class.
As a result of genome and other sequencing projects, the gap between the number of known protein sequences and the number of known protein structural classes is widening rapidly. In order to narrowExpand
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Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and the fourth most lethal cancer in China. However, although genomic studies have identified some mutationsExpand
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The rno‐miR‐34 family is upregulated and targets ACSL1 in dimethylnitrosamine‐induced hepatic fibrosis in rats
The mechanisms whereby hepatic fibrosis develops in chronic liver diseases remain incompletely defined. Here, we sought to examine whether microRNA (miRNA) became dysregulated inExpand
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Predicting protein structural class with pseudo-amino acid composition and support vector machine fusion network.
Because a priori knowledge of a protein structural class can provide useful information about its overall structure, the determination of protein structural class is a quite meaningful topic inExpand
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Single S-tapered fiber Mach-Zehnder interferometers.
A fiber Mach-Zehnder interferometer (MZI) sensor, novel to our knowledge, based on a single "S"-like fiber taper has been fabricated via applying nonaxial pull in fiber tapering by a fusion splicer.Expand
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Using Chou's amphiphilic pseudo-amino acid composition and support vector machine for prediction of enzyme subfamily classes.
With the rapid increment of protein sequence data, it is indispensable to develop automated and reliable predictive methods for protein function annotation. One approach for facilitating proteinExpand
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Two Gene Co-expression Modules Differentiate Psychotics and Controls
Schizophrenia (SCZ) and bipolar disorder (BD) are highly heritable psychiatric disorders. Associated genetic and gene expression changes have been identified, but many have not been replicated andExpand
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