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Comprehensive genomic characterization of head and neck squamous cell carcinomas
The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that… Expand
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
Lung cancer is the most common cause of cancer death worldwide, with over one million cases annually. To identify genetic factors that modify disease risk, we conducted a genome-wide association… Expand
Sleep Deprivation Causes Behavioral, Synaptic, and Membrane Excitability Alterations in Hippocampal Neurons
- C. McDermott, G. Lahoste, C. Chen, Alberto E. Musto, N. Bazan, J. Magee
- Biology, Medicine
- The Journal of Neuroscience
- 22 October 2003
Although the function of sleep remains elusive, several lines of evidence suggest that sleep has an important role in learning and memory. In light of the available data and with the prevalence of… Expand
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer
Testicular germ cell tumors (TGCT) have been expected to have a strong underlying genetic component. We conducted a genome-wide scan among 277 TGCT cases and 919 controls and found that seven markers… Expand
Lung cancer susceptibility locus at 5p15.33
We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33,… Expand
Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium.
- J. Heck, J. Berthiller, +25 authors M. Hashibe
- International journal of epidemiology
- 1 February 2010
BACKGROUND Sexual contact may be the means by which head and neck cancer patients are exposed to human papillomavirus (HPV). METHODS We undertook a pooled analysis of four population-based and four… Expand
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been… Expand
A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.
Down syndrome (DS) is caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is the most common genetic cause for developmental cognitive disability. The regions on Hsa21 are… Expand
Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity.
The functional significance of cyclooxygenases (COX-1 and -2), the key enzymes that convert arachidonic acid (AA) to prostaglandins (PGs) in brain, is unclear, although they have been implicated in… Expand
Genetic Factors in Catechol Estrogen Metabolism in Relation to the Risk of Endometrial Cancer
- J. Doherty, N. Weiss, +7 authors C. Chen
- Cancer Epidemiology Biomarkers & Prevention
- 1 February 2005
2-Hydroxylated metabolites of estrogen have been shown to have antiangiogenic effects and inhibit tumor cell proliferation, whereas 4-hydroxylated metabolites have been implicated in carcinogenesis.… Expand