• Publications
  • Influence
TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico
  • C. Chen
  • Medicine
  • PloS one
  • 6 January 2011
Rapid advancing computational technologies have greatly speeded up the development of computer-aided drug design (CADD). Recently, pharmaceutical companies have increasingly shifted their attentionsExpand
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Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids
  • S. Brown, G. Xia, +8 authors S. Walker
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 1 October 2012
Staphylococcus aureus peptidoglycan (PG) is densely functionalized with anionic polymers called wall teichoic acids (WTAs). These polymers contain three tailoring modifications: d-alanylation,Expand
  • 150
  • 12
  • Open Access
Evolutionary Expansion, Gene Structure, and Expression of the Rice Wall-Associated Kinase Gene Family1[w]
The wall-associated kinase (WAK) gene family, one of the receptor-like kinase (RLK) gene families in plants, plays important roles in cell expansion, pathogen resistance, and heavy-metal stressExpand
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  • 10
  • Open Access
Oral microbiome and oral and gastrointestinal cancer risk
A growing body of evidence implicates human oral bacteria in the etiology of oral and gastrointestinal cancers. Epidemiological studies consistently report increased risks of these cancers in men andExpand
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Treatment of Rheumatoid Arthritis with Traditional Chinese Medicine
Rheumatoid arthritis (RA) is a chronic inflammatory disease that will affect quality of life and, working efficiency, and produce negative thoughts for patients. Current therapy of RA is treated withExpand
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  • 4
  • Open Access
Screening from the World's Largest TCM Database Against H1N1 Virus
Abstract The swine influenza virus (H1N1) 2009 pandemic highlights the importance of having effective anti-viral strategies. Recently, oseltamivir (Tamiflu) resistant influenza viruses areExpand
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In silico pharmacology suggests ginger extracts may reduce stroke risks.
Aberrations in cyclic adenosine monophosphate (cAMP) signaling cascade has been linked to the allergic responses that associate with the risks of stroke or cardiovascular diseases. PhosphodiesteraseExpand
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A novel integrated framework and improved methodology of computer-aided drug design.
  • C. Chen
  • Biology, Medicine
  • Current topics in medicinal chemistry
  • 1 May 2013
Computer-aided drug design (CADD) is a critical initiating step of drug development, but a single model capable of covering all designing aspects remains to be elucidated. Hence, we developed a drugExpand
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  • 2
In Silico Design of BACE1 Inhibitor for Alzheimer's Disease by Traditional Chinese Medicine
The β-site APP cleaving enzyme 1 (BACE1) is an important target for causing Alzheimer's disease (AD), due to the brain deposition peptide amyloid beta (Aβ) require cleavages of amyloid precursorExpand
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  • 2
  • Open Access
Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once?
Based on genome wide association studies (GWAS), the activities of phosphodiesterase 4D (PDE4D) and 5-Lipoxygenase activating protein (ALOX5AP) were suggested as two of the major factors involved inExpand
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