C. Chen

Publications212
h-index44
Citations5,931
Highly Influential Citations143
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Mechanism of gating of T-type calcium channels
  • C. Chen, P. Hess
  • Chemistry, Medicine
  • The Journal of general physiology
  • 1 September 1990
We have analyzed the gating kinetics of T-type Ca channels in 3T3 fibroblasts. Our results show that channel closing, inactivation, and recovery from inactivation each include a voltage-independent… Expand
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  • 15
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Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation.
In isolated rat heart mitochondria lipid peroxidation was induced with ADP and ferrous sulfate (FeSO4). Oxygen consumption and malondialdehyde (MDA) production were measured to quantitate lipid… Expand
  • 214
  • 6
Gastrodin and p-hydroxybenzyl alcohol facilitate memory consolidation and retrieval, but not acquisition, on the passive avoidance task in rats.
Gastrodin (GAS) and p-hydroxybenzyl alcohol (HBA) which is an aglycone of gastrodin, are active ingredients of Gastrodia elata Blume. In this study, we attempted to investigate the effects of acute… Expand
  • 109
  • 5
Anti-inflammatory effects of the partially purified extract of radix Stephaniae tetrandrae: comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear…
We hypothesized that prevention of neutrophil from activation may underlie the myocardial protective effect of the specially processed extract of radix Stephaniae tetrandrae (SPRST). Inflammatory… Expand
  • 82
  • 5
Impediment to calcium influx and reactive oxygen production accounts for the inhibition of neutrophil Mac-1 Up-regulation and adhesion by tetrandrine.
We studied the mechanisms by which the plant alkaloid tetrandrine (TTD) inhibits Mac-1-dependent neutrophil adhesion to fibrinogen. TTD (0.1-10 microM) significantly inhibited Mac-1 up-regulation and… Expand
  • 35
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The Neuroprotective Effects of Phytoestrogens on Amyloid β Protein-induced Toxicity Are Mediated by Abrogating the Activation of Caspase Cascade in Rat Cortical Neurons*
Amyloid β protein (Aβ) elicits a toxic effect on neurons in vitro and in vivo. In present study we attempt to elucidate the mechanism by which Aβ confers its neurotoxicity. The neuroprotective… Expand
  • 171
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Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs.
In the present study, we established receptor binding assays to evaluate the water extracts of ten central nervous system (CNS)-active Chinese herbal drugs. These ten herbal drugs are Chaihu (Radix… Expand
  • 106
  • 4
The effects of the cyclosporin A, a P‐glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study
Baicalein is a bioactive flavonoid isolated from the root of Scutellaria baicalensis Georgi, a medicinal herb that has been used since ancient times to treat bacterial infections. As little is known… Expand
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Dynamic modeling of articulated vehicles for automated highway systems
  • C. Chen, M. Tomizuka
  • Engineering
  • Proceedings of American Control Conference - ACC…
  • 21 June 1995
TLDR
This paper is concerned with dynamic modeling of articulated vehicles in automated highway systems (AHS). Expand
  • 54
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Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum.
Bioassay-directed fractionation led to the identification of four known coumarins, osthole (1), imperatorin (2), xanthotoxin (3), and isopimpinellin (4), from the ethanolic extract of the fruit of… Expand
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