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Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis
- Z. Zou, Zhi-rui Zhou, C. Che, Chang-yun Liu, R. He, H. Huang
- Biology, Medicine
- Journal of Neurology, Neurosurgery & Psychiatry
- 5 January 2017
Background Genetic studies have shown that C9orf72, SOD1, TARDBP and FUS are the most common mutated genes in amyotrophic lateral sclerosis (ALS). Here, we performed a meta-analysis to determine the… Expand
Clinical Genetics of Alzheimer's Disease
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and the most common form of dementia in the elderly. It is a complex disorder with environmental and genetic… Expand
Toward precision medicine in amyotrophic lateral sclerosis.
Precision medicine is an innovative approach that uses emerging biomedical technologies to deliver optimally targeted and timed interventions, customized to the molecular drivers of an individual's… Expand
DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses.
- C. Liu, Zhenhua Zhao, +9 authors H. Huang
- Biology, Medicine
- Experimental and therapeutic medicine
- 1 September 2017
Endothelial dysfunction, regarded as a key step in the pathophysiological course of diabetic vascular complications, is initiated and deteriorated by advanced glycation end products (AGEs).… Expand
Novel mutation in optineurin causing aggressive ALS+/−frontotemporal dementia
- S. Feng, C. Che, +5 authors Z. Zou
- Annals of clinical and translational neurology
- 1 December 2019
Mutations in optineurin (OPTN) have been identified in familial and sporadic amyotrophic lateral sclerosis (ALS). We screened a cohort of Chinese patients for mutations in optineurin. We also… Expand
Factors Associated with Generic and Disease-specific Quality of Life in Epilepsy
Objective To investigate the association between quality of life (QOL) and sociodemographic factors, clinical seizure factors, depression and anxiety in patients suffering from epilepsy.
Factors associated with generic and disease-specific quality of life in epilepsy.
- H. Huang, C. Che, Chang-yun Liu, Fang Jiang, Xiaohong Mao
- Biomedical and environmental sciences : BES
OBJECTIVE To investigate the association between quality of life (QOL) and sociodemographic factors, clinical seizure factors, depression and anxiety in patients suffering from epilepsy. METHODS We… Expand
Diffusion Tensor Imaging With Tract-Based Spatial Statistics Reveals White Matter Abnormalities in Patients With Vascular Cognitive Impairment
Purpose: The aim of this study was to evaluate microstructural changes of major white matter (WM) tracts in patients with vascular cognitive impairment (VCI). Method: Diffusion tensor imaging (DTI)… Expand
Comparative Efficacy and Safety of Nine Anti-Platelet Therapies for Patients with Ischemic Stroke or Transient Ischemic Attack: a Mixed Treatment Comparisons
- H. Huang, Wan-hui Lin, Sheng-gen Chen, L. Chen, M. Chen, C. Che
- Molecular Neurobiology
- 1 March 2017
Anti-platelet treatments, an effective anti-thrombotic therapy, are widely used in non-cardioembolic ischemic stroke or transient ischemic attack (TIA), including aspirin, cilostazol, clopidogrel,… Expand
A Neurofibromatosis Type 1 Patient With Thoracic Encapsulated Fluid and Intracranial Hypotension Syndrome: A Case Report
IntroductionSpinal meningoceles are uncommon entities, mostly associated with neurofibromatosis type 1 (NF-1). Their intrusion into the thoracic cavity, which compresses lung tissue, is quite often… Expand