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Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse
Kisspeptin is encoded by the Kiss1 gene, and kisspeptin signaling plays a critical role in reproduction. In rodents, kisspeptin neurons in the arcuate nucleus (Arc) provide tonic drive toExpand
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The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System
Stress is a complex human experience having both positive and negative motivational properties. When chronic and uncontrollable, the adverse effects of stress on human health are considerable and yetExpand
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κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses
Previous studies have demonstrated that stress may increase prodynorphin gene expression, and κ opioid agonists suppress drug reward. Therefore, we tested the hypothesis that stress-induced releaseExpand
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Dynorphin is a specific endogenous ligand of the kappa opioid receptor.
In the guinea pig ileum myenteric plexus--longitudinal muscle preparation, dynorphin-(1--13) and the prototypical kappa agonist ethylketocyclazocine had equally poor sensitivity to naloxoneExpand
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Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance
Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective drugs known for acute relief of severe pain. A major problem in treating painful conditions is that toleranceExpand
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Distinct Domains of the CB1 Cannabinoid Receptor Mediate Desensitization and Internalization
Desensitization of cannabinoid receptor signaling by a G-protein coupled receptor kinase (GRK) was examined using theXenopus oocyte expression system. Application of a CB1 agonist, WIN 55,212-2,Expand
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Prior Activation of Kappa Opioid Receptors by U50,488 Mimics Repeated Forced Swim Stress to Potentiate Cocaine Place Preference Conditioning
Repeated forced-swim stress (FSS) produced analgesia, immobility and potentiation of cocaine-conditioned place preference (CPP) in wild-type C57Bl/6 mice, but not in littermates lacking the kappaExpand
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The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
Stress is a complex experience that carries both aversive and motivating properties. Chronic stress causes an increase in the risk of depression, is well known to increase relapse of drug seekingExpand
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Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A).
Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein common to all synaptic and endocrine vesicles. Unlike many proteins involved in synaptic exocytosis, SV2 has no homolog in yeast,Expand
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Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive
Stressors motivate an array of adaptive responses ranging from ‘fight or flight’ to an internal urgency signal facilitating long-term goals. However, traumatic or chronic uncontrollable stressExpand
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