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Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development
TLDR
It is shown that palatal rugae are sequentially added to the growing palate, in an interposition process that appears to be dependent on activation-inhibition mechanisms and reveals a new developmental boundary in thegrowing palate.
FGF Signaling Regulates the Number of Posterior Taste Papillae by Controlling Progenitor Field Size
TLDR
This work reports that a balance between Sprouty (Spry) genes and Fgf10, which respectively antagonize and activate receptor tyrosine kinase (RTK) signaling, regulates the number of CVPs, and provides the first demonstration of the role of epithelial-mesenchymal FGF signaling in taste papilla development.
Mosaic Convergence of Rodent Dentitions
TLDR
This work shows that the most derived functional condition associates longitudinal chewing and non interlocking of cusps within muroids and reveals a mosaic evolution of mammalian dentition in which direction of chewing and crown shape seem to be partly decoupled.
A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition
TLDR
It is shown that hypomorphic mutation of a cell surface receptor, Lrp4, produces incisors with grooved enamel surfaces that exhibit the same molecular characteristics as the tips of molar cusps, suggesting that mammals have the capacity to form multicuspid teeth regardless of location in the oral jaw.
Distinct Impacts of Eda and Edar Loss of Function on the Mouse Dentition
TLDR
This study reveals that losses of function of Eda and Edar have distinct impacts on the tooth size and morphology, contrary to what has previously been thought.
Modulation of Fgf3 dosage in mouse and men mirrors evolution of mammalian dentition
TLDR
It is reported that alterations in dosage of the Fgf3 gene cause morphological changes in both genetically engineered mutant mice and in human patients, and it is proposed that modifications in the FGF signaling pathway have played an important role in evolution of mammalian dentition by giving rise to new cusps and interconnecting cusp by new crests.
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling
TLDR
It is indicated that altering genetic dosage of an antagonist can recapitulate ancestral dental characters, and that tooth number can be progressively regulated by changing levels of activity of a single signal transduction pathway.
Evolutionary Trends of the Pharyngeal Dentition in Cypriniformes (Actinopterygii: Ostariophysi)
TLDR
By mapping morphological results in a phylogenetic tree, it emerges that the two super-families Cobitoidea and Cyprinoidea have followed two distinct evolutionary pathways and the hypothesis of a three-row dentition as ancestral for Cypriniformes is supported.
Evolutionary and developmental dynamics of the dentition in Muroidea and Dipodoidea (Rodentia, Mammalia)
TLDR
Documenting the morphological evolution of the P4–M1 complex across 14 extinct and extant species found that, even if their dental evolutionary pathways strongly differ, Dipodoidea and Muroidea retain common developmental characteristics because some of them can present similar dental morphological trends.
Roles of dental development and adaptation in rodent evolution.
TLDR
This study finds that overexpression of Eda or Edar is sufficient to produce the longitudinal crests defining stephanodonty in transgenic laboratory mice, and demonstrates how combining development and function can help to evaluate adaptive scenarios in the evolution of new morphologies.
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