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The infectivity of Cryptosporidium parvum in healthy volunteers.
TLDR
In healthy adults with no serologic evidence of past infection with C. parvum, a low dose of C.Parvum oocysts is sufficient to cause infection, and there were no secondary cases of diarrhea among household contacts.
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Risk assessment for Cryptosporidium: a hierarchical Bayesian analysis of human dose response data.
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Virulence of three distinct Cryptosporidium parvum isolates for healthy adults.
TLDR
Three Cryptosporidium parvum isolates of the C genotype differ in their infectivity for humans, and a trend toward a longer duration of diarrhea was seen for the TAMU versus UCP and Iowa isolates.
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CRYPTOSPORIDIOSIS
View on Elsevier
Cryptosporidium hominis: experimental challenge of healthy adults.
TLDR
The infectivity, illness, and serologic response after experimental challenge of 21 healthy adult volunteers with 10-500 C. hominis (TU502) oocysts is described and greatest responses were seen in volunteers with diarrhea and oocyst shedding.
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Cryptosporidium parvum: intensity of infection and oocyst excretion patterns in healthy volunteers.
TLDR
Experimental infection in 29 antibody-negative, healthy, adult volunteers generated information on the dose-infection response of C. parvum (Iowa strain), and oocyst shedding patterns were investigated, revealing that volunteers with diarrheal illness excreted more oocysts over the course of the infection than did volunteers without diarrhea.
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Cryptosporidium Dose Response Studies: Variation Between Isolates
TLDR
This work has found that three different isolates of the waterborne protozoan parasite Cryptosporidium parvum have different ID50s, indicating substantial variation in their infectivity for humans.
View on Wiley
Infectivity of Cryptosporidium parvum in healthy adults with pre-existing anti-C. parvum serum immunoglobulin G.
TLDR
Data indicate that prior exposure to C. parvum provides protection from infection and illness at low oocyst doses in healthy adults with pre-existing anti-C.Parvum antibodies.
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Susceptibility and Serologic Response of Healthy Adults to Reinfection with Cryptosporidium parvum
TLDR
Although the rates of diarrhea were comparable after each of the two exposures, the clinical severity as determined by the mean number of unformed stools passed was lower after reexposure, and the number of anti-Cryptosporidium immunoglobulin G and A seroconversions increased after secondary exposure, but the C. parvumserum antibody response did not correlate with the presence or absence of infection.
View on ASMUSA
The Role of Hepatitis C in Hepatocellular Carcinoma: A Case Control Study Among Egyptian Patients
TLDR
Both HCV and hepatitis B virus infection increase the risk of HCC in Egyptian patients, whereas isolated Schistosoma infection does not.
View on Wolters Kluwer
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