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The infectivity of Cryptosporidium parvum in healthy volunteers.
In healthy adults with no serologic evidence of past infection with C. parvum, a low dose of C.Parvum oocysts is sufficient to cause infection, and there were no secondary cases of diarrhea among household contacts. Expand
Virulence of three distinct Cryptosporidium parvum isolates for healthy adults.
Three Cryptosporidium parvum isolates of the C genotype differ in their infectivity for humans, and a trend toward a longer duration of diarrhea was seen for the TAMU versus UCP and Iowa isolates. Expand
Cryptosporidium hominis: experimental challenge of healthy adults.
The infectivity, illness, and serologic response after experimental challenge of 21 healthy adult volunteers with 10-500 C. hominis (TU502) oocysts is described and greatest responses were seen in volunteers with diarrhea and oocyst shedding. Expand
Purpose of review Cryptosporidiosis is a self-limited diarrheal disease that occurs in the community setting but can be chronic and potentially serious in immunocompromised patients. CommunityExpand
Cryptosporidium parvum: intensity of infection and oocyst excretion patterns in healthy volunteers.
Experimental infection in 29 antibody-negative, healthy, adult volunteers generated information on the dose-infection response of C. parvum (Iowa strain), and oocyst shedding patterns were investigated, revealing that volunteers with diarrheal illness excreted more oocysts over the course of the infection than did volunteers without diarrhea. Expand
Risk assessment for Cryptosporidium: a hierarchical Bayesian analysis of human dose response data.
Three dose-response studies were conducted with healthy volunteers using different Cryptosporidium parvum isolates (IOWA, TAMU, and UCP) and data were analyzed using a hierarchical Bayesian model to derive risk of infection from single oocyst doses and the utility of these results for probabilistic risk assessment was evaluated. Expand
Infectivity of Cryptosporidium parvum in healthy adults with pre-existing anti-C. parvum serum immunoglobulin G.
Data indicate that prior exposure to C. parvum provides protection from infection and illness at low oocyst doses in healthy adults with pre-existing anti-C.Parvum antibodies. Expand
The antibody response to 27-, 17-, and 15-kDa Cryptosporidium antigens following experimental infection in humans.
It is suggested that characteristic antibody responses develop following C. parvum infection and that persons with preexisting antibodies may be less likely to develop illness. Expand
The Role of Hepatitis C in Hepatocellular Carcinoma: A Case Control Study Among Egyptian Patients
Both HCV and hepatitis B virus infection increase the risk of HCC in Egyptian patients, whereas isolated Schistosoma infection does not. Expand
Cryptosporidium dose response studies: variation between isolates.
This work has found that three different isolates of the waterborne protozoan parasite Cryptosporidium parvum have different ID50s, indicating substantial variation in their infectivity for humans. Expand