C. Chang

Publications95
h-index53
Citations11,769
Highly Influential Citations423
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Distribution of androgen and estrogen receptor mRNA‐containing cells in the rat brain: An in situ hybridization study
TLDR
AR and ER may modulate nonolfactory sensory information as well since labeled cells were found in regions involved in the central relay of somatosensory information, including the mesencephalic nucleus of the trigeminal nerve, the ventral thalamic nuclear group, and the dorsal horn of the spinal cord.
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The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.
Nodal proteins have crucial roles in mesendoderm formation and left-right patterning during vertebrate development. The molecular mechanisms of signal transduction by Nodal and related ligands,…
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From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.
TLDR
It is demonstrated that the growth of prostate cancer LNCaP cells can also be increased by the stable transfection of HER2/Neu, and this may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients.
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Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.
  • S. Yeh, C. Chang
  • Biology
    Proceedings of the National Academy of Sciences…
  • 28 May 1996
TLDR
Using a yeast two-hybrid system, a ligand-dependent AR-associated protein (ARA70), which functions as an activator to enhance AR transcriptional activity 10-fold in the presence of 10(-10) M dihydrotestosterone or 10(-9) M testosterone, is isolated.
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Cloning and Characterization of Androgen Receptor Coactivator, ARA55, in Human Prostate*
TLDR
The cloning of a novel AR coactivator ARA55 using a yeast two-hybrid system and Northern blot and polymerase chain reaction quantitation showed ARA 55 can be expressed differently in normal prostate and prostate tumor cells suggests that ARA56 may play very important roles in the progression of prostate cancer by the modulation of AR transactivation.
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The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans.
TLDR
A screen for Caenorhabditis elegans mutants that affect context-dependent gene silencing in somatic tissues yielded multiple alleles of a previously uncharacterized gene, designated tam-1 (for tandem-array-modifier), which led to a dramatic reduction in the activity of numerous highly repeated transgenes.
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Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population-based case-control study in China.
TLDR
This study not only confirms that Chinese men do have a longer CAG repeat length than western men but also represents the first population-based study to show that even in a very low-risk population, a shorter C AG repeat length confers a higher risk of clinically significant prostate cancer.
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Caenorhabditis elegans SOS‐1 is necessary for multiple RAS‐mediated developmental signals
TLDR
Analyzing vulval development in a let‐341 null mutant, it is found that an SOS‐1‐independent pathway involved in the activation of RAS signaling is not inhibited by SLI‐1/Cbl and is not mediated by PTP‐2/SHP, raising the possibility that there could be another RasGEF.
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Molecular cloning of human and rat complementary DNA encoding androgen receptors.
TLDR
Complementary DNAs (cDNAs) encoding androgen receptors were obtained from human testis and rat ventral prostate cDNA libraries and indicated the presence of a cysteine-rich DNA-binding domain that is highly conserved in all steroid receptors.
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Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.
TLDR
Molecular hybridization studies, using AR cDNAs as probes, indicated that the ventral prostate and other male accessory organs are rich in AR mRNA and that the production of AR mRNA in the target organs may be autoregulated by androgens.
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