Identification of deoxymiroestrol as the actual rejuvenating principle of "Kwao Keur", Pueraria mirifica. The known miroestrol may be an artifact.
- S. Chansakaow, T. Ishikawa, H. Seki, K. Sekine (née Yoshizawa), M. Okada, C. Chaichantipyuth
- BiologyJournal of Natural Products
- 27 January 2000
Reinvestigation using bioassay-guided purification has resulted in the isolation of a new potent phytoestrogen, deoxymiroestrol, and the facile aerial oxidation of 2 into 1 suggests the possibility that 1 may be an artifact.
Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-α, and COX-2 expression in mouse macrophage RAW 264.7
Examination of the inhibitory effects of the known oxycoumarins poncitrin, osthol, and xanthoxyletin, newly isolated from Clausena guillauminii, revealed that the synthesis of nitric oxide (NO) and the protein expression of tumor necrosis factor-α and cyclooxygenase-2 (COX-2) were inhibited by 5.7 μM.
Isoflavonoids from Pueraria mirifica and their estrogenic activity.
Nine isoflavonoids including a new pterocarpene, puemiricarpenes, were isolated from the tuberous root of Pueraria mirifica using spectroscopic means and moderate activity was observed for kwakhurin, a prenylated is oflavonoid.
Hepatoprotective activity of Thunbergia laurifolia Linn extract in rats treated with ethanol: in vitro and in vivo studies.
The protective effects of Phyllanthus emblica Linn. extract on ethanol induced rat hepatic injury.
Bioactive constituents of Melodorum fruticosum
Hepatoprotective activity of Phyllanthus amarus Schum. et. Thonn. extract in ethanol treated rats: in vitro and in vivo studies.
CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk.
Quantitative analysis of miroestrol and kwakhurin for standardisation of Thai miracle herb ‘Kwao Keur’ (Pueraria mirifica) and establishment of simple isolation procedure for highly estrogenic…
- Satoko Shimokawa, Takuya Kumamoto, S. Chansakaow
- Biology, MedicineNatural Product Research
- 1 March 2013
Quantitative analysis of miroestrol (1) and kwakhurin (3) by HPLC, leading to standardisation of commercially available Thai miracle herb ‘Kwao Keur’ which has been identified with Pueraria mirifica,…