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Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme.
Recent advances in single molecule manipulation methods offer a novel approach to investigating the protein folding problem. These studies usually are done on molecules that are naturally organizedExpand
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Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism.
The established strand-displacement model for mammalian mitochondrial DNA (mtDNA) replication has recently been questioned in light of new data using two-dimensional (2D) agarose gel electrophoresis.Expand
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Analysis of P Element Transposase Protein-DNA Interactions during the Early Stages of Transposition*
P elements are a family of transposable elements found in Drosophila that move by using a cut-and-paste mechanism and that encode a transposase protein that uses GTP as a cofactor for transposition.Expand
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A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis
The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has aExpand
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Small heat shock proteins: multifaceted proteins with important implications for life
Small Heat Shock Proteins (sHSPs) evolved early in the history of life; they are present in archaea, bacteria, and eukaryota. sHSPs belong to the superfamily of molecular chaperones: they areExpand
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Guanosine triphosphate acts as a cofactor to promote assembly of initial P-element transposase-DNA synaptic complexes.
P transposable elements in Drosophila are members of a larger class of mobile elements that move using a cut-and-paste mechanism. P-element transposase uses guanosine triphosphate (GTP) as a cofactorExpand
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mechanism with alternative light-strand origins , not via a strand-coupled Replication of mitochondrial DNA occurs by strand displacement data
data Supplementary http://www.genesdev.org/cgi/content/full/19/20/2466/DC1 "Supplemental Research Data" References http://www.genesdev.org/cgi/content/full/19/20/2466#References This article cites 41Expand
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The Complex Conformational Dynamics of Neuronal Calcium Sensor-1: A Single Molecule Perspective
The human neuronal calcium sensor-1 (NCS-1) is a multispecific two-domain EF-hand protein expressed predominantly in neurons and is a member of the NCS protein family. Structure-functionExpand
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Structure, Folding Dynamics, and Amyloidogenesis of D76N β2-Microglobulin
Background: We recently discovered the first natural human β2-microglobulin variant, D76N, as an amyloidogenic protein. Results: Fluid flow on hydrophobic surfaces triggers its amyloidExpand
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DNA molecular handles for single-molecule protein-folding studies by optical tweezers.
In this chapter, we describe a method that extends the use of optical tweezers to the study of the folding mechanism of single protein molecules. This method entails the use of DNA molecules asExpand
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