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RoB 2: a revised tool for assessing risk of bias in randomised trials
TLDR
The Cochrane risk-of-bias tool has been updated to respond to developments in understanding how bias arises in randomised trials, and to address user feedback on and limitations of the original tool.
Continuous positive airways pressure for obstructive sleep apnoea in adults.
TLDR
CPAP is effective in reducing symptoms of sleepiness and improving quality of life measures in people with moderate and severe obstructive sleep apnoea (OSA).
Continuous positive airways pressure for obstructive sleep apnoea in adults.
TLDR
CPAP is effective in reducing symptoms of sleepiness and improving quality of life measures in people with moderate and severe obstructive sleep apnoea (OSA).
Influenza vaccine for patients with chronic obstructive pulmonary disease.
TLDR
It appears, from the limited number of studies performed, that inactivated vaccine may reduce exacerbations in COPD patients, and was due to a reduction in exacerbations occurring three or more weeks after vaccination.
Comparison of the effectiveness of inhaler devices in asthma and chronic obstructive airways disease: a systematic review of the literature.
TLDR
No demonstrable difference is found in the clinical bronchodilator effect of short-acting b2-agonists delivered by the standard pMDI compared with that produced by any other DPI, HFA-pMDI or the Autohaler device.
Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma.
TLDR
Metered-dose inhalers with spacer produced outcomes that were at least equivalent to nebuliser delivery, and Spacers may have some advantages compared to neBulisers for children with acute asthma.
Culture-specific programs for children and adults from minority groups who have asthma.
TLDR
Current limited data show that culture-specific programmes for adults and children from minority groups with asthma, are more effective than generic programmes in improving most (quality of life, asthma knowledge, asthma exacerbations, asthma control) but not all asthma outcomes.
Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis.
TLDR
A network meta-analysis was conducted using Markov chain Monte Carlo methods for two efficacy outcomes: St George's Respiratory Questionnaire (SGRQ) total score and trough forced expiratory volume in one second (FEV1).
A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils)
TLDR
It was concluded that tailoring of asthma treatment based on sputum eosinophils is effective in decreasing asthma exacerbations and there is insufficient justification to advocate the routine use of eitherSputum analysis or FeNO in everyday clinical practice.
Cardioselective beta-blockers for chronic obstructive pulmonary disease.
TLDR
The available evidence suggests that cardioselective beta-blockers, given to patients with COPD do not produce a significant short-term reduction in airway function or in the incidence of COPD exacerbations.
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