• Publications
  • Influence
Kibaran events in the southernmost Mozambique belt
Abstract An area of ∼ 20 000 km2 in northern Mozambique has been mapped at 1 : 50 000 scale. The dominant, ∼ 1000 Ma old Lurian event (Kibaran orogeny) produced the “Namama belt” — a SE vergentExpand
  • 64
  • 6
Mechanism and pressor relevance of the short-term cardiovascular and renin excitatory actions of the selective A2A-adenosine receptor agonists.
Selective A2A adenosine receptor agonists are potent vasodilators that reduce blood pressure and induce marked increments in heart rate and plasma renin activity (PRA). To examine the mechanisms andExpand
  • 23
  • 4
Cardiovascular pharmacology of the A2A adenosine receptor antagonist, SCH 58261, in the rat.
We characterized the in vivo cardiovascular profile of SCH 58261, 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2, 4-triazolo[1,5-c] pyrimidine, a selective A2A adenosine receptorExpand
  • 54
  • 3
  • PDF
Repeated administration of selective adenosine A1 and A2 receptor agonists in the spontaneously hypertensive rat: tolerance develops to A1-mediated hemodynamic effects.
We investigated the effects of the selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA), the selective A2 adenosine agonistsExpand
  • 38
  • 2
Modeling hemodynamic profiles by telemetry in the rat. A study with A1 and A2a adenosine agonists.
The newly developed radiotelemetry system offers a number of advantages for the measurement of blood pressure and heart rate in laboratory animals. However, no available statistical methods permitExpand
  • 17
  • 1
Telemetry monitoring of hemodynamic effects induced over time by adenosine agonists in spontaneously hypertensive rats.
Using the telemetry system in spontaneously hypertensive rats (SHR), we evaluated the hemodynamic effects of four adenosine analogs having different selectivity for A1 and A2a adenosine receptorExpand
  • 20
  • 1
Pharmacology of the new selective A2a adenosine receptor agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine.
The pharmacological profile of 2-hexynyl-5'-N-ethylcarboxamidoadenosine (2HE-NECA, CAS 141018-30-6), a new selective A2a adenosine receptor agonist, was characterized. In binding studies on both ratExpand
  • 27
  • 1
Hemodynamic and Humoral Effects of Chronic Treatment with the Neutral Endopeptidase Inhibitor SCH 42495 in Spontaneously Hypertensive Rats
Summary: Blockade of atrial natriuretic factor (ANF) degradation by specific neutral endopeptidase (NEP) inhibitors may be useful in treatment of hypertension because of the potential diuretic,Expand
  • 10
  • 1
Pharmacology of the highly selective A1 adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine.
The pharmacological profile of 2-chloro-N6-cyclopentyladenosine (CCPA, CAS 37739-05-2), a highly selective A1 adenosine receptor agonist, was characterized. Its effects were compared with those ofExpand
  • 32