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Interleukin‐10 modulates neuronal threshold of vulnerability to ischaemic damage
A potential neuroprotective role of IL‐10 against cerebral ischaemia when administered exogenously or made available from endogenous sources is suggested.
Mechanism and pressor relevance of the short-term cardiovascular and renin excitatory actions of the selective A2A-adenosine receptor agonists.
The results suggest that the increase in heart rate and in PRA induced by A2A agonists is the result of a reflex increase in sympathetic activity triggered by the decrease in blood pressure, and the reactive activation of the renin-angiotensin system elicited by these compounds may contribute to blunting their antihypertensive effect.
STANDING, a four-step bedside algorithm for differential diagnosis of acute vertigo in the Emergency Department
SOUNDING seems to be a promising simple structured bedside algorithm that in this preliminary study identified central AV with a very high sensitivity, and was associated with significant reduction of neuroimaging and hospitalisation rates.
Cardiovascular pharmacology of the A2A adenosine receptor antagonist, SCH 58261, in the rat.
The data indicate that SCH 58261 retains A2A selective receptor antagonist properties in vivo, and its effect on cardiovascular sympathetic outflow further suggests that endogenous adenosine exerts a tonic vascular regulation through A1 receptors.
Repeated administration of selective adenosine A1 and A2 receptor agonists in the spontaneously hypertensive rat: tolerance develops to A1-mediated hemodynamic effects.
As expected, the A1 agonist CCPA induced a dose-dependent bradycardia, whereas the A2 agonists had minimal influence on HR, and the nonselective agonist NECA induced brady Cardia only at the two highest doses.
Modeling hemodynamic profiles by telemetry in the rat. A study with A1 and A2a adenosine agonists.
This study describes elaboration and testing of mathematical functions as applied to the measurement of the effects of drugs on blood pressure and heart rate in spontaneously hypertensive rats, using parametric functions analogous to those for pharmacokinetic studies.
Can emergency physicians accurately and reliably assess acute vertigo in the emergency department?
To validate a clinical diagnostic tool, used by emergency physicians (EPs), to diagnose the central cause of patients presenting with vertigo, and to determine interrater reliability of this tool.
Telemetry monitoring of hemodynamic effects induced over time by adenosine agonists in spontaneously hypertensive rats.
At equiactive doses, the antihypertensive effects of adenosine agonists were shorter lasting [t1/2 for DBP were: CCPA, 54 (44-76) min, 2HE-NECA, 57 (46-71) min; CGS 21680, 45 (21-94) min) and NECA, 61(38-97) min]; than those of felodipine, which caused tachycardia.
Pharmacology of the new selective A2a adenosine receptor agonist 2-hexynyl-5'-N-ethylcarboxamidoadenosine.
The pharmacological profile of 2-hexynyl-5'-N-ethylcarboxamidoadenosine (2HE-NECA, CAS 141018-30-6), a new selective A2a adenosine receptor agonist, was characterized and showed a good A 2a vs A1 receptor selectivity in brain tissues of both animal species.