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In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent.
Characteristic DNA migration patterns (laddering) provide evidence of apoptosis (programmed cell death) in testicular tissue of rats administered CdCl2 at a level of 0.03 mmol/kg 48 h previously. Expand
Polymerase chain reaction amplification of three different Trypanosoma cruzi DNA sequences from human chagasic cardiac tissue.
The results suggest that the quantity of T. cruzi DNA persisting in hearts of patients with Chagas' disease correlates with cardiomyopathy, but may not be preferentially associated with inflammatory foci. Expand
In vitro trypanocidal activity of tetraethylthiuram disulfide and sodium diethylamine-N-carbodithioate on Trypanosoma cruzi.
Tetraethylthiuram disulfide (disulfiram) and sodium diethylamine-N-carbodithioate (DECD) and both drugs are candidates for further study to determine if they are of potential clinical interest as a prophylactic or therapeutic agent against Chagas' disease. Expand
Multienzymic nature of pyruvate kinase during development of Hymenolepis diminuta (Cestoda).
H. diminuta at different stages of development contained as many as five pyruvate kinase isozymes, four of which were unusually sensitive to allosteric activation by fructose-1,6-P2 and one which occurred only in adults or near-adults but had a relatively low Km. Expand
Cadmium-induced apoptosis in the urogenital organs of the male rat and its suppression by chelation.
Cadmium-induced apoptosis is shown to occur, in vivo, in several organs of the male Wistar rat urogenital system, 48 h after cadmium administration i.p. at a dose of 0.03 mmol/kg. Characteristic DNAExpand
Properties of glycogen synthase and phosphorylase from Biomphalaria glabrata (mollusca).
Glycogen synthase and phosphorylase were characterized from the cephalopedal region of the snail, Biomphalaria glabrata, and demonstrated interconversion of its two forms, as evidenced by changes in its activity ratio. Expand
An electrophoretic analysis of Schistosoma mansoni soluble egg antigen preparation.
An immunoelectrophoretic analysis of SEA reveals at least 5 distinct precipitin arcs when developed with serum from mice infected with S. mansoni for 16 weeks. Expand
Detection of Trypanosoma cruzi with the polymerase chain reaction and in situ hybridization in infected murine cardiac tissue.
Polymerase chain reaction amplification of extracted DNA from hematoxylin and eosin-stained tissue scrapings and in situ hybridization are used to detect the presence of Trypanosoma cruzi in infected murine cardiac tissue sections, indicating that PCR and in vitro hybridization may prove useful in establishing the prevalence of T.cruzi in human chagasic cardiomyopathy. Expand
PGE2 regulates cAMP production in cultured rabbit CCD cells: evidence for dual inhibitory mechanisms.
In cultured cortical collecting duct (CCD) cells, exogenous prostaglandin E2 inhibited arginine vasopressin (AVP)-stimulated adenosine 3',5'-cyclic monophosphate (cAMP) production in a concentration-dependent manner and PT and staurosporine, a protein kinase C inhibitor, together partially reversed the effect of exogenous PGE2. Expand
Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis.
A therapeutic potential is suggested for the CM101 target protein HP59 both as a drug target and as a vaccine against pathoangiogenesis. Expand