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Mechanistic Data and Risk Assessment of Selected Toxic End Points of the Thyroid Gland
- C. Capen
- Chemistry, MedicineToxicologic pathology
- 1 January 1997
A consistent finding with all of these goitrogens, be they either physiologic perturbations or xenobiotics, is the chronic hypersecretion of TSH, which places the rodent thyroid gland at greater risk to develop tumors through a secondary (indirect) mechanism of thyroid oncogenesis associated with hormonal imbalances.
Adrenal Gland: Structure, Function, and Mechanisms of Toxicity
- T. Rosol, J. Yarrington, J. Latendresse, C. Capen
- Biology, MedicineToxicologic pathology
- 1 January 2001
The adrenal gland is one of the most common endocrine organs affected by chemically induced lesions and lesions are more frequent in the zona fasciculata and reticularis than in theZona glomerulosa; Morphologic evaluation of cortical lesions provides insight into the sites of inhibition of steroidogenesis.
Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.
These findings indicate that ret/PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papilla thyroid carcinoma.
Calcium-Regulating Hormones and Diseases of Abnormal Mineral (Calcium, Phosphorus, Magnesium) Metabolism
Publisher Summary Calcium (Ca) is a mineral that plays a central role in maintaining the homeostasis of vertebrate animals, including muscle contraction, blood coagulation, enzyme activity, neural…
Neoplastic Lesions of Questionable Significance to Humans
An overview of current understanding is provided, with particular reference to renal tumors in male rats with α2μ-globulin nephropathy, urinary bladder neoplasia in rodents, mesovarian leiomyomas induced in rats by β2-receptor stimulants, carcinoid tumors in the rodent stomach induced by prolonged suppression of acid secretion.
Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas.
It is demonstrated that the lack of functional p53 in ret/PTC1 mice promotes anaplasia and invasiveness of thyroid carcinomas.
Pathophysiology of chemical injury of the thyroid gland.
- C. Capen
- Chemistry, MedicineToxicology letters
- 1 December 1992
A consistent finding with all of these goitrogenic chemicals is the chronic hypersecretion of TSH which places the rodent thyroid gland at greater risk to develop tumors through a secondary mechanism of thyroid oncogenesis.
Adrenal Cortical Carcinomas with Myxoid Differentiation in the Domestic Ferret (Mustela putorius furo)
This report is the first description of this histologic variant in the ferret, which morphologically resembled the rare myxoid variant of adrenocortical carcinoma described in humans.
The toxicological evaluation of the mycotoxins T-2 and T-2 tetraol using normal human fibroblasts in vitro.
- J. W. Oldham, L. E. Allred, G. Milo, O. Kindig, C. Capen
- Biology, MedicineToxicology and applied pharmacology
Normal human fibroblasts in vitro were used as a system to examine the cellular effects of potentially toxic compounds and multiple biochemical parameters with ultrastructural and cytotoxicity studies were effective in demonstrating the mechanisms as well as the degree of toxicity induced by these chemical compounds.