Mechanistic Data and Risk Assessment of Selected Toxic End Points of the Thyroid Gland
- C. Capen
- Biology, MedicineToxicologic pathology (Print)
- 1 January 1997
A consistent finding with all of these goitrogens, be they either physiologic perturbations or xenobiotics, is the chronic hypersecretion of TSH, which places the rodent thyroid gland at greater risk to develop tumors through a secondary (indirect) mechanism of thyroid oncogenesis associated with hormonal imbalances.
Adrenal Gland: Structure, Function, and Mechanisms of Toxicity
- T. Rosol, J. Yarrington, J. Latendresse, C. Capen
- Biology, MedicineToxicologic pathology (Print)
- 1 January 2001
The adrenal gland is one of the most common endocrine organs affected by chemically induced lesions and lesions are more frequent in the zona fasciculata and reticularis than in theZona glomerulosa; Morphologic evaluation of cortical lesions provides insight into the sites of inhibition of steroidogenesis.
Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.
- S. Jhiang, J. Sagartz, C. Ledent
- Medicine, BiologyEndocrinology
- 1996
These findings indicate that ret/PTC2 is not only a biomarker associated with papillary thyroid carcinomas, but is also the only proven specific genetic event leading to the development of papilla thyroid carcinoma.
Tumors of the Endocrine Glands
- C. Capen
- Medicine
- 14 April 2008
Neoplastic Lesions of Questionable Significance to Humans
- R. Alison, C. Capen, D. Prentice
- Medicine, BiologyToxicologic pathology (Print)
- 1 March 1994
An overview of current understanding is provided, with particular reference to renal tumors in male rats with α2μ-globulin nephropathy, urinary bladder neoplasia in rodents, mesovarian leiomyomas induced in rats by β2-receptor stimulants, carcinoid tumors in the rodent stomach induced by prolonged suppression of acid secretion.
Loss of p53 promotes anaplasia and local invasion in ret/PTC1-induced thyroid carcinomas.
- K. L. La Perle, S. Jhiang, C. Capen
- Medicine, BiologyAmerican Journal of Pathology
- 1 August 2000
Pathophysiology of chemical injury of the thyroid gland.
- C. Capen
- Biology, MedicineToxicology Letters
- 1 December 1992
Adrenal Cortical Carcinomas with Myxoid Differentiation in the Domestic Ferret (Mustela putorius furo)
- R. Peterson, M. Kiupel, C. Capen
- Medicine, BiologyVeterinary Pathology-Supplement
- 1 March 2003
This report is the first description of this histologic variant in the ferret, which morphologically resembled the rare myxoid variant of adrenocortical carcinoma described in humans.
Structural and functional properties of adult rat heart myocytes lysed with digitonin.
- R. Altschuld, W. Wenger, G. Brierley
- BiologyJournal of Biological Chemistry
- 15 November 1985
...
...