Pro-nociceptive effects of neuromedin u in rat
- X. Yu, C. Cao, M. Perkins
- BiologyNeuroscience
- 22 August 2003
A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain
- Xiao Hong Yu, C. Cao, J. Laird
- Biology, ChemistryPain
- 1 November 2010
Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain
- A. Serrano, Michel Paré, C. Cao
- Biology, MedicineMolecular Pain
- 1 January 2010
In vitro and in vivo pharmacological approaches using a novel C CR2 antagonist, AZ889, strengthened the hypothesis of a CCR2 contribution to neuropathy-induced pain and provided confidence over the possibilities to treat neuropathic pain with CCR1 antagonists.
A pro-nociceptive role of neuromedin U in adult mice
- C. Cao, Xiao Hong Yu, A. Dray, A. Filosa, M. Perkins
- Biology, MedicinePain
- 1 August 2003
Control of P2X3 Channel Function by Metabotropic P2Y2 UTP Receptors in Primary Sensory Neurons
- G. Mo, J. Peleshok, C. Cao, A. Ribeiro-da-Silva, P. Séguéla
- BiologyMolecular Pharmacology
- 1 March 2013
It is proposed that expression of P2Y2 purinoceptor in nociceptive sensory neurons provides an homeostatic mechanism to prevent excessive ATP signaling through P2X3 receptor channels.
Differential Expression and Pharmacology of Native P2X Receptors in Rat and Primate Sensory Neurons
- A. Serrano, G. Mo, C. Cao
- BiologyJournal of Neuroscience
- 22 August 2012
It is demonstrated that monkey and human dorsal root ganglion (DRG) neurons do not express appreciable levels of P2X2 subunit, contrary to rat sensory neurons, and key mechanisms impacting the translatability of potential analgesics targeting P2x3 receptors are identified.
Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors
- G. Mo, L. Bernier, P. Séguéla
- BiologyMolecular Pain
- 1 January 2009
Evidence is reported that phospholipids involved in functional modulation of several types of ion channels are able to modulate the function of homomeric P2X3 and heteromericP2X2/3 purinoceptors expressed in dorsal root ganglion (DRG) nociceptors and in heterologous expression systems.
Spinal delta-opioid receptors mediate suppression of systemic SNC80 on excitability of the flexor reflex in normal and inflamed rat.
- C. Cao, Y. Hong, A. Dray, M. Perkins
- Biology, ChemistryEuropean Journal of Pharmacology
- 20 April 2001
Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase.
- C. Scott, G. Tian, P. Edwards
- Biology, ChemistryEuropean Journal of Pharmacology
- 30 September 2011
Discovery and Pharmacological Characterization of a Small-Molecule Antagonist at Neuromedin U Receptor NMUR2
- Jay Liu, K. Payza, J. Bostwick
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 July 2009
R-PSOP is the first antagonist ever reported for NMU receptors and could serve as a valuable tool for further understanding the physiological and pathophysiological roles of NMU system, while providing a chemical starting point that may lead to development of new therapeutics for treatment of eating disorders, obesity, pain, and stress-related disorders.
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