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Phages and the Evolution of Bacterial Pathogens: from Genomic Rearrangements to Lysogenic Conversion
The current review presents the available genomics and biological data on prophages from bacterial pathogens in an evolutionary framework to demonstrate that the chromosomes from bacteria and their viruses (bacteriophages) are coevolving. Expand
Genomics of Actinobacteria: Tracing the Evolutionary History of an Ancient Phylum
An account of the recent explosion of actinobacterial genomics data is provided and an attempt to place this in a biological and evolutionary context. Expand
Complete Genome Sequence of the Prototype Lactic Acid Bacterium Lactococcus lactis subsp. cremoris MG1363
The availability of the L. lactis MG1363 genome sequence will reinforce its status as the prototype among lactic acid bacteria through facilitation of further applied and fundamental research. Expand
The impact of prophages on bacterial chromosomes
Prophages were automatically localized in se‐quenced bacterial genomes by a simple semantic script leading to the identification of 190 prophages in 115 investigated genomes, and fixation of prophage genes seems to be restricted to those with functions that have been co‐opted by the bacterial host. Expand
Phage as agents of lateral gene transfer.
Prophages constitute in many bacteria a substantial part of laterally acquired DNA and contribute lysogenic conversion genes that are of selective advantage to the bacterial host. Expand
Multireplicon genome architecture of Lactobacillus salivarius.
The discovery of megaplasmids of widely varying size in L. salivarius suggests a possible mechanism for genome expansion or contraction to adapt to different environments. Expand
Analysis of bifidobacterial evolution using a multilocus approach.
Bifidobacteria represent one of the most numerous groups of bacteria found in the gastrointestinal tract of humans and animals. In man, gastrointestinal bifidobacteria are associated with healthExpand
Prophage Genomics
Analysis of the prophages suggested that after being integrated into bacterial genomes, they undergo a complex decay process consisting of inactivating point mutations, genome rearrangements, modular exchanges, invasion by further mobile DNA elements, and massive DNA deletion. Expand
Comparative and Functional Analysis of Sortase-Dependent Proteins in the Predicted Secretome of Lactobacillus salivarius UCC118
A comparative bioinformatic analysis of four publicly available Lactobacillus genomes and the genome of L. salivarius strain UCC118 was performed to identify secreted proteins and those linked to the cell wall. Expand
Microbial diversity in the human intestine and novel insights from metagenomics.
A thorough understanding of the autochthonous component of the intestinal microbiota is expected to provide crucial information not only on how to develop therapies for various gastrointestinal diseases but also onHow to choose the next generation of probiotic bacteria as part of novel functional foods. Expand