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Travoprost compared with latanoprost and timolol in patients with open-angle glaucoma or ocular hypertension.
- C. Camras
- American journal of ophthalmology
- 1 May 2002
The average ocular hyperemia score was less than 1 on a scale of 0 to 3, indicating that on average patients experienced between none/trace and mild for all treatment groups, and there were no serious, unexpected, related adverse events reported for any therapy. Expand
Comparison of latanoprost and timolol in patients with ocular hypertension and glaucoma: a six-month masked, multicenter trial in the United States. The United States Latanoprost Study Group.
- C. Camras
Intraocular pressure was significantly reduced and maintained by both medications without evidence of a long-term drift over 6 months, and latanoprost has the potential for becoming a new first-line treatment for glaucoma. Expand
Reduction of intraocular pressure by prostaglandins applied topically to the eyes of conscious rabbits.
The present experiments suggest that exogenous administration of low doses of certain PG's or their analogues may aid in the treatment of ocular hypertension and that endogenous PG synthesis may, in some cases, contribute to or actually mediate the profound hypotony that often follows ocular trauma and inflammation. Expand
Aqueous humor dynamics in the aging human eye.
In the healthy aging eye, there is a Reduction in the production of aqueous humor and a reduction in its drainage through the uveoscleral outflow pathway. Expand
Effects of exogenous prostaglandins on aqueous humor dynamics and blood-aqueous barrier function.
- C. Toris, C. Camras, M. Yablonski, R. Brubaker
- Chemistry, Medicine
- Survey of ophthalmology
- 1 February 1997
In vitro and in vivo studies of the effects of PGs on aqueous humor dynamics and BAB integrity in humans, cats and monkeys indicate that PGs may directly modulate extracellular matrix metabolism, which may be related to the increased uveoscleral drainage. Expand
Aqueous Humor Dynamics in Ocular Hypertensive Patients
The increased IOP in ocular hypertensive patients is caused by a reduction in trabecular outflow facility and uveoscleral outflow and when both ocular normotensive and hypertensive groups are combined, aqueous flow and anterior chamber volume decrease slightly with age. Expand
Commercially available prostaglandin analogs for the reduction of intraocular pressure: similarities and differences.
A review of numerous prospective, randomized comparative studies indicates that no clinically significant differences exist among these prostaglandin analogs regarding their ability to lower intraocular pressure. Expand
PRDX6 attenuates oxidative stress- and TGFβ-induced abnormalities of human trabecular meshwork cells
- N. Fatma, E. Kubo, C. Toris, W. Stamer, C. Camras, D. P. Singh
- Biology, Medicine
- Free radical research
- 1 January 2009
It is demonstrated that peroxiredoxin (PRDX) 6, an antioxidant, offsets the deleterious effects of oxidative stress on TM cells by optimizing ROS and TGFβ levels and provides a foundation for antioxidant-based therapeutics for treating glaucoma. Expand
Effects of brimonidine on aqueous humor dynamics in human eyes.
The brimonidine-induced reduction in IOP in humans is associated with a decrease in aqueous flow and an increase in uveoscleral outflow, which suggests a mild contralateral effect. Expand
Latanoprost and cystoid macular edema: is there a causal relation?
Review of all published cases indicates that all eyes had independent risk for development of CME, so that definitive conclusions about a causal relation cannot be established, and reports of a possible association between CME and latanoprost use must be given serious consideration. Expand