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Gamma Interferon Secretion by Human Vγ2Vδ2 T Cells after Stimulation with Antibody against the T-Cell Receptor plus the Toll-Like Receptor 2 Agonist Pam3Cys
TLDR
A functional TLR2 that requires coincident TCR stimulation may increase the initial potency of Vγ2Vδ2 T-cell responses at the site of infection and promote the rapid development of subsequent acquired antipathogen immunity. Expand
Gamma interferon secretion by human Vgamma2Vdelta2 T cells after stimulation with antibody against the T-cell receptor plus the Toll-Like receptor 2 agonist Pam3Cys.
TLDR
A functional TLR2 that requires coincident TCR stimulation may increase the initial potency of Vgamma2Vdelta2 T-cell responses at the site of infection and promote the rapid development of subsequent acquired antipathogen immunity. Expand
Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates.
TLDR
DNA array analysis of human peripheral blood mononuclear cells from healthy donors exposed to ML29 revealed that gene expression patterns in ML29-exposed PBMC and control, media-exp exposed PBMC, clustered together confirming safety profile of the ML29 in non-human primates. Expand
Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local
TLDR
The goal was to examine obstacles preventing effective Vγ9Vδ2 T cell therapy and strategies for overcoming them, and focus on the potential for local activation of Vγ 9V Δ2 T cells within the tumor environment to increase potency and achieve objective responses during cancer therapy. Expand
Reference Values of Lymphocyte Subsets in Healthy, HIV-Negative Children in Cameroon
TLDR
The immunological profile for children aged from birth through 6 years in Cameroon is reported and lymphocyte subset reference values among children from Cameroon differ from reported values in Caucasian and some African populations. Expand
Impact of age, gender, and race on circulating γδ T cells.
TLDR
Mechanisms for selection and amplification of Vδ2 cells are nearly identical for both groups, despite the significant difference in baseline levels, and appropriate controls, matched for age and race, may be required for clinical studies of Vγ2V δ2 T cells in infectious disease or cancer. Expand
Impacts of HIV infection on Vγ2Vδ2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS
TLDR
HIV infection has multiple impacts on the circulating Vγ2Vδ2 T cell population that combine to reduce the potential effector activity in terms of tumor cytotoxicity and may be important factors for elevating the risk of malignancy during AIDS. Expand
Human cord blood γδ T cells expressing public Vγ2 chains dominate the response to bisphosphonate plus interleukin‐15
TLDR
The Vγ2Vδ2 T cells present in neonates are capable of generating potent immune responses even when relying on IL‐15.2, and may be a result of limited exposure to stimulatory phosphoantigens, lack of T‐cell‐derived interleukin‐2 (IL‐2) or both. Expand
Differentiation of Monocytes Into CD1a− Dendritic Cells Correlates With Disease Progression in HIV-Infected Patients
TLDR
The results suggest that the differentiation of monocytes into CD1a− DCs may be a phenotypic marker associated with progression of the disease. Expand
Lack of CD27−CD45RA−Vγ9Vδ2+ T Cell Effectors in Immunocompromised Hosts and During Active Pulmonary Tuberculosis1
TLDR
It is observed that two subsets of Vγ9Vδ2+ T cells could be identified on the basis of CD27 expression in immunocompetent adults, showing that functionally differentiated γδ T cells have lost CD27expression. Expand
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