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Pulsed cavitational ultrasound therapy for controlled tissue homogenization.
Methods were investigated to acoustically control the extent to which cavitation-mediated tissue homogenization is responsible for lesion formation in vitro. These results may guide potentialExpand
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Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney.
PURPOSE The optimal minimally invasive treatment for small renal masses continues to evolve. Current ablative technologies rely on thermal mechanisms for tissue destruction. However, the creation ofExpand
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Controlled ultrasound tissue erosion: the role of dynamic interaction between insonation and microbubble activity.
Previous studies showed that ultrasound can mechanically remove tissue in a localized, controlled manner. Moreover, enhanced acoustic backscatter is highly correlated with the erosion process.Expand
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Probability of cavitation for single ultrasound pulses applied to tissues and tissue-mimicking materials.
In this study, the negative pressure values at which inertial cavitation consistently occurs in response to a single, two-cycle, focused ultrasound pulse were measured in several media relevant toExpand
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Cost-effective assembly of a basic fiber-optic hydrophone for measurement of high-amplitude therapeutic ultrasound fields.
Design considerations, assembly details, and operating procedures of one version of a cost-effective basic fiber-optic probe hydrophone (FOPH) are described in order to convey practical informationExpand
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Noninvasive thrombolysis using pulsed ultrasound cavitation therapy - histotripsy.
Clinically available thrombolysis techniques are limited by either slow reperfusion (drugs) or invasiveness (catheters) and carry significant risks of bleeding. In this study, the feasibility ofExpand
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Cavitation clouds created by shock scattering from bubbles during histotripsy.
Histotripsy is a therapy that focuses short-duration, high-amplitude pulses of ultrasound to incite a localized cavitation cloud that mechanically breaks down tissue. To investigate the mechanism ofExpand
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Time-temperature analysis of cell killing of BHK cells heated at temperatures in the range of 43.5°C to 57.0°C☆
Abstract Baby hamster kidney (BHK) cells were heated at temperatures in the range of 43.5°C to 57.0°C to determine the time-temperature relationship of cell killing. The cells were grown on 0.025 mmExpand
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Disintegration of tissue using high intensity focused ultrasound: Two approaches that utilize shock waves
Introduction Surgery is moving more and more toward minimally-invasive procedures – using laparoscopic approaches with instruments inserted through tiny incisions or catheters placed in blood vesselsExpand
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Optimization of the intensity gain of multiple-focus phased-array heating patterns.
A new technique for enhancing the intensity gain at the focal points in multiple-focus patterns is introduced. The new technique is shown to be effective in reducing the interference typicallyExpand
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