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[13C2]-Acetaldehyde promotes unequivocal formation of 1,N2-propano-2'-deoxyguanosine in human cells.
TLDR
The unequivocal formation of 1,N(2)-propanodGuo in cells exposed to this aldehyde can be used to elucidate the mechanisms associated with acetaldehyde exposure and cancer risk. Expand
Oxidative and alkylating damage in DNA.
TLDR
This work addresses the importance of isotope labeling associated with mass spectrometry technique for biomolecule damage studies and provides the first evidence of the occurrence of 1,N(2)-epsilondGuo as a basal endogenous lesion and may be utilized to better assess the biological consequences of etheno DNA damage under normal and pathological conditions. Expand
DNA damage as a biological sensor for environmental sunlight.
TLDR
The data demonstrate the applicability of DNA-based biosensors as alternative, complementary, and reliable methods for registering variations in the genotoxic impact of solar UV radiation and for determining the level of photoprotection sunscreens provided at thelevel of DNA damage and cell death. Expand
Long-term intermittent feeding, but not caloric restriction, leads to redox imbalance, insulin receptor nitration, and glucose intolerance.
TLDR
Overall, the results show that restricted diets are significantly different in their effects on glucose tolerance and redox state when adopted long-term, and show that intermittent feeding can lead to oxidative insulin receptor inactivation and glucose intolerance. Expand
The relative roles of DNA damage induced by UVA irradiation in human cells.
TLDR
It is confirmed that both types of photoproducts are the primary lesions responsible for inducing cell death in XP-A cells and may trigger the skin-damaging effects of UVA light, particularly skin ageing and carcinogenesis. Expand
Increased SOD1 association with chromatin, DNA damage, p53 activation, and apoptosis in a cellular model of SOD1-linked ALS.
TLDR
DNA damage, p53 activity and apoptosis in SH-SY5Y human neuroblastoma cells transfected to achieve low-level expression of either wild-type or mutant Gly(93)-->Ala (G93A) SOD1 indicate that the G93A mutant SOD 1 association with DNA might induce DNA damage and trigger the apoptotic response by activating p53. Expand
Development of an on-line liquid chromatography-electrospray tandem mass spectrometry assay to quantitatively determine 1,N(2)-etheno-2'-deoxyguanosine in DNA.
TLDR
The method described here provides the first evidence of the occurrence of 1,N(2)-etheno-2'-deoxyguanosine as a basal endogenous lesion and may be usefully employed to assess the biological consequences of etheno DNA damage under normal and pathological conditions. Expand
Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model.
TLDR
The role of lycopene as an antioxidant and anti-inflammatory agent in mice exposed to CS was elucidated and it was able to minimize redox processes by decreasing lipid peroxidation and DNA damage. Expand
The key role of UVA‐light induced oxidative stress in human Xeroderma Pigmentosum Variant cells
TLDR
The results strongly indicate the crucial role of oxidative stress in UVA‐induced cytotoxicity and are of interest for the protection of XP‐V patients, afflicted by exposure to sunlight. Expand
Brazilian Ironstone Plant Communities as Reservoirs of Culturable Bacteria With Diverse Biotechnological Potential
TLDR
It is discovered that cultivable bacterial isolates obtained from plants in the ferruginous rocky soil of the Iron Quadrangle region have diverse biotechnological potential, revealing a genetic ancestry still unknown. Expand
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