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Adsorption of alpha-helical antifreeze peptides on specific ice crystal surface planes.
The noncolligative peptide and glycopeptide antifreezes found in some cold-water fish act by binding to the ice surface and preventing crystal growth, not by altering the equilibrium freezing pointExpand
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The refined crystal structure of an eel pout type III antifreeze protein RD1 at 0.62-A resolution reveals structural microheterogeneity of protein and solvation.
RD1 is a 7-kDa globular protein from the Antarctic eel pout Lycodichthys dearborni. It belongs to type III of the four types of antifreeze proteins (AFPs) found in marine fishes living at subzeroExpand
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Antineoplastic agents. Structure-activity relationship study of bis(substituted aminoalkylamino)anthraquinones.
A structure-activity relationship study was conducted on a number of bis(substituted aminoalkylamino)anthraquinones. These compounds were prepared by the condensation of substituted or unsubstitutedExpand
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Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site.
[3H]Quinpirole is a dopamine agonist with high affinity for the D2 and D3 dopamine receptor subtypes. A variety of drugs, most notably monoamine oxidase inhibitors (MAOls), inhibit the binding ofExpand
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Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines.
Publisher Summary This chapter discusses the developments in the study of 2,4-diaminopyrimidines since 1970 and analogues as targets for the chemotherapy of infectious disease. This category ofExpand
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Experimental antileukemic agents. Coralyne, analogs, and related compounds.
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Pyrazole derivatives. 5. Synthesis and antineoplastic activity of 3-(2-chloroethyl)-3,4-dihydro-4-oxopyrazolo[5,1-d]-1,2,3, 5-tetrazine-8-carboxamide and related compounds.
Two pyrazolotetrazine derivatives were synthesized as the analogous prodrugs of the light-sensitive antineoplastic agents dacarbazine and BIC. Both the pyrazole derivatives are stable under ordinaryExpand
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Purification and characterization of antifreeze proteins from larvae of the beetle Dendroides canadensis
SummaryFour antifreeze proteins (AFPs) were purified from larvae of the beetle Dendroides canadensis. The AFPs are similar in amino acid compositions, having high contents of hydrophilic amino acidsExpand
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Common receptor-complement feature among some antileukemic compounds.
A common structural feature was found among some nonalkylating antileukemic agents such as aminopterin, anthramycin, 5-azacytidine, bisketopiperazines, camptothecin, cytosine arabinoside, daunomycin,Expand
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