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APOE genotype-specific differences in the innate immune response
TLDR
The data suggest that inhibition of inflammation depends upon the dose of apoE3 protein available and that apolipoprotein E and of the APOE genotype may alter inflammation partly by dose effects and partly by being qualitatively different than apOE3.
Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions
TLDR
It is demonstrated that a prolonged period of hypoestrogenicity disrupts both neuroprotective and antiinflammatory actions of E2, which may help to explain the results of the Women's Health initiative that reported no beneficial effect of ET against stroke.
Neuroprotective effects of estrogens following ischemic stroke
TLDR
The laboratory has discovered that low, physiological concentrations of E(2), which are strikingly similar to low-basal circulating levels found in cycling mice, dramatically protect the brain against stroke injury, and consequently revealed multiple signaling pathways and key genes that mediate protective action of E (2).
Arginine Deprivation and Immune Suppression in a Mouse Model of Alzheimer's Disease
TLDR
These findings strongly implicate local immune-mediated amino acid catabolism as a novel and potentially critical mechanism mediating the age-dependent and regional loss of neurons in humans with AD.
Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and beta.
TLDR
These studies identify a dramatic cytokine- and chemokine-mediated neuroinflammatory response that is regulated through ERα- and ERβ-mediated ligand-dependent and ligands-independent mechanisms.
Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years.
TLDR
CEE-based therapies produced no overall sustained benefit or risk to cognitive function when administered to postmenopausal women aged 50 to 55 years, and some evidence that CEE- based therapies may have adversely affected verbal fluency among women who had prior hysterectomy or prior use of hormone therapy is found.
Fueling the flame: bioenergy couples metabolism and inflammation
TLDR
The emerging concept that changes in cellular bioenergetics concomitantly reprogram inflammatory and metabolic responses is reviewed to identify new ways to treat inflammatory and immune diseases.
SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
TLDR
Findings reveal that modifying the SIRT1 NAD+ axis may provide a novel way to treat sepsis in its hypoinflammatory phase.
Simultaneous determination of 6 L-arginine metabolites in human and mouse plasma by using hydrophilic-interaction chromatography and electrospray tandem mass spectrometry.
TLDR
This new assay uses plasma metabolomic measurements to help provide new insights into metabolic changes coupled to the innate immune response and identified significant changes in arginine metabolism in both humans and mice following an inflammatory stimulus.
Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative.
TLDR
The results reveal that 17beta-estradiol slows the progression of this injury and diminishes the extent of cell death by suppressing apoptotic cell death pathways and enhancing expression of genes that optimize cell survival.
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