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APOE genotype-specific differences in the innate immune response
Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions
- Shotaro Suzuki, C. Brown, Christopher Dela Cruz, Enhua Yang, David A. Bridwell, P. Wise
- Biology, PsychologyProceedings of the National Academy of Sciences
- 3 April 2007
It is demonstrated that a prolonged period of hypoestrogenicity disrupts both neuroprotective and antiinflammatory actions of E2, which may help to explain the results of the Women's Health initiative that reported no beneficial effect of ET against stroke.
Arginine Deprivation and Immune Suppression in a Mouse Model of Alzheimer's Disease
These findings strongly implicate local immune-mediated amino acid catabolism as a novel and potentially critical mechanism mediating the age-dependent and regional loss of neurons in humans with AD.
Neuroprotective effects of estrogens following ischemic stroke
Fueling the flame: bioenergy couples metabolism and inflammation
The emerging concept that changes in cellular bioenergetics concomitantly reprogram inflammatory and metabolic responses is reviewed to identify new ways to treat inflammatory and immune diseases.
Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years.
CEE-based therapies produced no overall sustained benefit or risk to cognitive function when administered to postmenopausal women aged 50 to 55 years, and some evidence that CEE- based therapies may have adversely affected verbal fluency among women who had prior hysterectomy or prior use of hormone therapy is found.
Simultaneous determination of 6 L-arginine metabolites in human and mouse plasma by using hydrophilic-interaction chromatography and electrospray tandem mass spectrometry.
This new assay uses plasma metabolomic measurements to help provide new insights into metabolic changes coupled to the innate immune response and identified significant changes in arginine metabolism in both humans and mice following an inflammatory stimulus.
SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
Findings reveal that modifying the SIRT1 NAD+ axis may provide a novel way to treat sepsis in its hypoinflammatory phase.
Mechanisms of neuroprotection by estrogen
The results from the laboratory demonstrating that low physiological levels of estradiol therapy exert powerful protection against ischemic stroke-like injury are reviewed and work to decipher under what circumstances 17β-estradiol protects against neuronal death and to uncover its mechanisms of action is reviewed.
Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative.
The results reveal that 17beta-estradiol slows the progression of this injury and diminishes the extent of cell death by suppressing apoptotic cell death pathways and enhancing expression of genes that optimize cell survival.