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A MIXED LONGITUDINAL STUDY OF ADRENAL STEROID EXCRETION IN CHILDHOOD AND THE MECHANISM OF ADRENARCHE
TLDR
Urinary steroid metabolites have been measured by gas‐liquid chromatography and ratios of steroid metabolites used to draw conclusions about likely enzymic activities at each step in the adrenal biosynthetic pathway. Expand
The control of the onset of puberty.
TLDR
One that will refer to break the boredom in reading is choosing control of the onset of puberty as the reading material. Expand
Mechanism of Puberty
  • C. Brook
  • Medicine
  • Hormone Research in Paediatrics
  • 1 November 1999
TLDR
The hypothalamo-pituitary-gonadal axis in children is fully functional in fetal life and immediately after birth but gonadotropin pulsatility is at a nadir at 6 years of age, from that time pulsatile gonadtropin starts to reappear but, again, the reason why this happens is completely unknown. Expand
Birthweight between 14 and 42 weeks' gestation.
TLDR
Serial ultrasound measurement to assess fetal growth velocity is a more appropriate use of ultrasound compared with other methods of assessing gestational age because of the limitations of ultrasound. Expand
The effects of growth hormone therapy on spontaneous sexual development.
TLDR
The data suggest that both boys and girls had a more rapid rate of pubertal maturation than normal and may be that in terms of final height prognosis, the events of puberty related to GH treatment counterbalance the improvement in growth prognosis during prepuberty. Expand
Peak and trough growth hormone concentrations have different associations with the insulin-like growth factor axis, body composition, and metabolic parameters.
TLDR
It is suggested that the peak values of a GH concentration profile may influence the IGF axis, whereas trough values may influence body composition and metabolic parameters of GH action. Expand
Hypoplastic optic nerves and pituitary dysfunction. A spectrum of anatomical and endocrine abnormalities.
TLDR
Fourteen children with optic nerve hypoplasia associated with either mid-brain abnormalities or pituitary dysfunction, or both, are described and the importance of hypoglycaemia in the neonatal period and later in childhood is emphasised in relation to diagnosis and developmental delay. Expand
The measurement of growth hormone bioactivity in patient serum using an eluted stain assay.
TLDR
Following the changes in bioactivity and immunoactivity of hGH in multiple timed samples after stimulation of h GH secretion in an adult by GHRH, systematic and progressive changes were observed in the bioactive/immunoactive ratios. Expand
INDUCTION OF PUBERTY BY PULSATILE GONADOTROPIN RELEASING HORMONE
TLDR
It is found that normal puberty is GnRH dependent and patients with delayed or arrested puberty treated with GnRH had constitutional delay of growth and puberty. Expand
Management of Growth Hormone Deficiency Through Puberty
ABSTRACT. As a model of the growth hormone (GH) dependence of growth in prepuberty and puberty, the growth of 182 children (93 boys, 89 girls) who survived in first remission for treatment of acuteExpand
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