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A MIXED LONGITUDINAL STUDY OF ADRENAL STEROID EXCRETION IN CHILDHOOD AND THE MECHANISM OF ADRENARCHE
Urinary steroid metabolites have been measured by gas‐liquid chromatography and ratios of steroid metabolites used to draw conclusions about likely enzymic activities at each step in the adrenal biosynthetic pathway.
The control of the onset of puberty.
- C. Brook, R. Stanhope, P. Hindmarsh, J. Adams
- MedicineActa endocrinologica. Supplementum
- 1 December 1986
One that will refer to break the boredom in reading is choosing control of the onset of puberty as the reading material.
The effects of growth hormone therapy on spontaneous sexual development.
The data suggest that both boys and girls had a more rapid rate of pubertal maturation than normal and may be that in terms of final height prognosis, the events of puberty related to GH treatment counterbalance the improvement in growth prognosis during prepuberty.
Mechanism of Puberty
- C. Brook
- Biology, MedicineHormone Research in Paediatrics
- 1 November 1999
The hypothalamo-pituitary-gonadal axis in children is fully functional in fetal life and immediately after birth but gonadotropin pulsatility is at a nadir at 6 years of age, from that time pulsatile gonadtropin starts to reappear but, again, the reason why this happens is completely unknown.
Birthweight between 14 and 42 weeks' gestation.
Serial ultrasound measurement to assess fetal growth velocity is a more appropriate use of ultrasound compared with other methods of assessing gestational age because of the limitations of ultrasound.
EXPERIENCE WITH HUMAN GROWTH HORMONE IN GREAT BRITAIN: THE REPORT OF THE MRC WORKING PARTY
Demand for hGH may soon outstrip supply, research conducted on behalf of the Working Party suggests that hCH deficiency is more common than has been thought and that the prevalence may be as high as one in 10000.
Peak and trough growth hormone concentrations have different associations with the insulin-like growth factor axis, body composition, and metabolic parameters.
- P. Hindmarsh, C. Fall, P. Pringle, C. Osmond, C. Brook
- Medicine, BiologyJournal of Clinical Endocrinology and Metabolism
- 1 July 1997
It is suggested that the peak values of a GH concentration profile may influence the IGF axis, whereas trough values may influence body composition and metabolic parameters of GH action.
Hypoplastic optic nerves and pituitary dysfunction. A spectrum of anatomical and endocrine abnormalities.
Fourteen children with optic nerve hypoplasia associated with either mid-brain abnormalities or pituitary dysfunction, or both, are described and the importance of hypoglycaemia in the neonatal period and later in childhood is emphasised in relation to diagnosis and developmental delay.
The measurement of growth hormone bioactivity in patient serum using an eluted stain assay.
- M. Dattani, P. Hindmarsh, P. Pringle, C. Brook, N. J. Marshall
- Biology, MedicineThe Journal of clinical endocrinology and…
- 1 September 1995
Following the changes in bioactivity and immunoactivity of hGH in multiple timed samples after stimulation of h GH secretion in an adult by GHRH, systematic and progressive changes were observed in the bioactive/immunoactive ratios.