Randomized Trial of Benznidazole for Chronic Chagas' Cardiomyopathy.
- C. Morillo, J. Marin-Neto, S. Yusuf
- MedicineNew England Journal of Medicine
- 30 September 2015
Trypanocidal therapy with benznidazole in patients with established Chagas' cardiomyopathy significantly reduced serum parasite detection but did not significantly reduce cardiac clinical deterioration through 5 years of follow-up.
International Study to Evaluate PCR Methods for Detection of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients
- A. Schijman, M. Bisio, Janis Ladzins
- MedicinePLoS Neglected Tropical Diseases
- 1 January 2011
This study represents a first crucial step towards international validation of PCR procedures for detection of T. cruzi in human blood samples by an external quality evaluation.
Polymerase chain reaction detection of Trypanosoma cruzi in human blood samples as a tool for diagnosis and treatment evaluation
- C. Britto, M. A. Cardoso, P. Wincker
- MedicineParasitology
- 1 April 1995
It is suggested that PCR is the most sensitive technique available for direct detection of T. cruzi in chagasic patients and that it can be a very useful instrument for the follow-up of patients after specific treatment.
Use of a simplified polymerase chain reaction procedure to detect Trypanosoma cruzi in blood samples from chronic chagasic patients in a rural endemic area.
- P. Wincker, C. Britto, J. Pereira, M. A. Cardoso, W. Oelemann, C. Morel
- MedicineAmerican Journal of Tropical Medicine and Hygiene
- 1 May 1995
Identification of naturally infected Lutzomyia intermedia and Lutzomyia migonei with Leishmania (Viannia) braziliensis in Rio de Janeiro (Brazil) revealed by a PCR multiplex non-isotopic…
- Daniela de Pita-Pereira, C. R. Alves, C. Britto
- BiologyTransactions of the Royal Society of Tropical…
- 1 December 2005
Use of a Simplified Polymerase Chain Reaction Procedure to Detect Trypanosoma cruzi in Blood Samples from Chronic Chagasic Patients in a Rural Endemic Area
- P. Wincker, C. Britto, J. Pereira, M. A. Cardoso, W. Oelemann, C. Morel
- Medicine
- 1 December 1994
The results suggest that the PCR may be a useful complement to serology in the diagnosis of Chagas' disease, and that it is the most powerful technique available for parasite detection in patients with chronic disease.
Peculiar sequence organization of kinetoplast DNA minicircles from Trypanosoma cruzi.
- W. Degrave, S. Fragoso, C. Morel
- BiologyMolecular and biochemical parasitology (Print)
- 1988
A simple protocol for the physical cleavage of Trypanosoma cruzi kinetoplast DNA present in blood samples and its use in polymerase chain reaction (PCR)-based diagnosis of chronic Chagas disease.
- C. Britto, M. A. Cardoso, P. Wincker, C. Morel
- MedicineMemórias do Instituto Oswaldo Cruz
- 1993
Usefulness of PCR-based assays to assess drug efficacy in Chagas disease chemotherapy: value and limitations.
- C. Britto
- MedicineMemórias do Instituto Oswaldo Cruz
- 1 July 2009
The main problems concerning drug efficacy and criteria used for cure estimation in treated chagasic patients are reviewed, and the work conducted by different groups on developing PCR methodologies to monitor treatment outcome of congenital infections as well as recent and late chronic T. cruzi infections is reviewed.
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