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Tubulin Is an Inherent Component of Mitochondrial Membranes That Interacts with the Voltage-dependent Anion Channel*
TLDR
It is shown by immunoprecipitation experiments that the mitochondrial tubulin is specifically associated with the voltage-dependent anion channel, the main component of the permeability transition pore, and it could play a role in apoptosis via interaction with the permeable Transition pore. Expand
Repair of Oxidized Proteins
TLDR
A new methionine sulfoxide reductase is identified, which is referred to as MsrB, the gene of which is present in genomes of eubacteria, archaebacteria, and eucaryotes and is required for cadmium resistance of E. coli. Expand
Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug‐induced apoptosis in neuroblastoma cells
TLDR
The results suggest that tau phosphorylation plays a significant role in apoptosis enhancing disruption of microtubules that in turn leads to formation of apoptotic bodies, suggesting that neurodegeneration and apoptosis are related. Expand
Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics
TLDR
The results indicate that microtubule dynamics play an important role in Taxol resistance, and that both excessively rapid dynamics and suppressed dynamics impair mitotic spindle function and inhibit proliferation. Expand
Thermodynamic analysis of calcium and magnesium binding to calmodulin.
TLDR
The results presented here challenge the current accepted view of CaM ion binding and suggest that Ca2-CaM interaction follows an enthalpy-entropy compensation relationship, suggesting that CaM explores a subspace of isoenergetical conformations which is modified by Ca2+ binding. Expand
Binding of ATP to Heat Shock Protein 90
TLDR
Results clearly demonstrate that hsp90 possesses a second ATP-binding site located on the C-terminal part of the protein and suggest allosteric interaction between N- and C-Terminal domains of hSp90. Expand
DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose.
TLDR
The first experimental evidence that clorobiocin binds gyrase with a stronger affinity than novobiocIn is provided, and the crucial role of both the hydroxybenzoate isopentenyl moiety and the 5'-alkyl group on the noviose of the coumarins in the binding affinity for gyrases is demonstrated. Expand
Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells'.
TLDR
It is shown for the first time that paclitaxel acts directly or mitochondria isolated from human cancer cells, and can directly affect mito chondria to induce apoptosis. Expand
Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells
TLDR
It is demonstrated that the direct mitochondrial effect of paclitaxel observed in vitro is relevant in intact SK‐N‐SH cells and targets mitochondria upstream of caspase activation, early during the apoptotic process in intact human neuroblastoma cells. Expand
Thermodynamics of heme binding to the HasA(SM) hemophore: effect of mutations at three key residues for heme uptake.
TLDR
It is demonstrated that, in contrast to His32, His83 is essential for the binding of heme to HasA(SM), even though it is not directly coordinated to iron, and that the Tyr75/His83 pair plays a key role in the interaction. Expand
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