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Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.
TLDR
A time-resolved FRET strategy based on receptor labeling with selective fluorescent ligands was developed and applied to native tissues and succeeded in demonstrating the presence of oxytocin receptor dimers and/or oligomers in mammary gland.
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Maternal stress alters endocrine function of the feto-placental unit in rats.
TLDR
Data emphasize the impact of PS on both fetal growth and endocrine function as well as on placental physiology, suggesting that PS could program processes implied in adult biology and pathophysiology.
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Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups.
TLDR
The data showed that maternal undernutrition drastically reduces the postnatal surge of plasma leptin, disturbing particularly the hypothalamic wiring as well as the gene expression of the anorexigenic POMC neurons in male rat pups, which might contribute to the adult metabolic disorders resulting from perinatal growth retardation.
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The hypothalamus-adipose axis is a key target of developmental programming by maternal nutritional manipulation.
  • C. Breton
  • Biology
    The Journal of endocrinology
  • 1 February 2013
TLDR
Hormonal and epigenetic mechanisms responsible for long-lasting programming of energy balance in the offspring are highlighted and dietary supplementation may provide a therapeutic option using a specific regimen for reversing adverse programming outcomes in humans.
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The D136A mutation of the V2 vasopressin receptor induces a constitutive activity which permits discrimination between antagonists with partial agonist and inverse agonist activities
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Oxytocin synthesis and oxytocin receptor expression by cell lines of human small cell carcinoma of the lung stimulate tumor growth through autocrine/paracrine signaling.
TLDR
Observations demonstrate the existence of a functional OT-mediated autocrine/paracrine signaling actively implicated in growth and development of SCCL tumors and point to the potential of OT antagonists for development as therapeutic agents for the treatment of S CCL.
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Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: evidence for an estrogen surface receptor.
TLDR
A physiological dose of estrogen acutely stimulates NO release from human monocytes via the activation of an estrogen surface receptor that is coupled to increases in intracellular calcium.
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Probing the Existence of G Protein-Coupled Receptor Dimers by Positive and Negative Ligand-Dependent Cooperative Binding
TLDR
Because positive cooperative binding cannot be explained without considering receptor as multivalent, these binding data support the concept of GPCR dimerization process and suggest that binding experiments can be used to probe the existence of receptor dimers.
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Maternal prenatal undernutrition alters the response of POMC neurons to energy status variation in adult male rat offspring.
Epidemiological studies suggest that maternal undernutrition predisposes the offspring to development of energy balance metabolic pathologies in adulthood. Using a model of a prenatal maternal 70%…
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Comparative biology of the endocannabinoid system
TLDR
The possible function of the endogenous cannabinoid system in the modulation of immune response in organisms from the lower to the higher levels of animal evolution is described.
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