• Publications
  • Influence
Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways
SUMMARY Addiction is a complex psychiatric disorder considered to be a disease of the brain's natural reward reinforcement system. Repeated stimulation of the `reward' pathway leads to adaptiveExpand
  • 131
  • 15
Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish.
The isolation and characterisation of two zebrafish Eph receptor ligand cDNAs which we have called zfEphL3 and zfEphL4 is described. These genes are expressed in the presumptive midbrain ofExpand
  • 125
  • 12
Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism.
In mammals, an AMP-activated protein kinase (AMPK) phosphorylates both acetyl-CoA carboxylase and 3-hydroxy-3-methylglutaryl-CoA reductase in vitro and has been proposed to play a major role in theExpand
  • 236
  • 9
Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo
Nerve activity is known to be an important regulator of muscle phenotype in the adult, but its contribution to muscle development during embryogenesis remains unresolved. We used the zebrafish embryoExpand
  • 58
  • 8
  • PDF
The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development
Exposure to moderate levels of ethanol during brain development has a number of effects on social behavior but the molecular mechanisms that mediate this are not well understood. Gaining a betterExpand
  • 61
  • 7
  • PDF
Housing Conditions Differentially Affect Physiological and Behavioural Stress Responses of Zebrafish, as well as the Response to Anxiolytics
Zebrafish are a widely utilised animal model in developmental genetics, and owing to recent advances in our understanding of zebrafish behaviour, their utility as a comparative model in behaviouralExpand
  • 82
  • 5
  • PDF
The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function
Zebrafish have great potential to contribute to our understanding of behavioral genetics and thus to contribute to our understanding of the etiology of psychiatric disease. However, progress isExpand
  • 71
  • 5
  • PDF
Discrimination reversal and attentional sets in zebrafish (Danio rerio)
The potential of zebrafish as a comparative model in behavioural neuroscience is currently hampered only by the lack of reliable and validated behavioural assays available to researchers. In theExpand
  • 58
  • 4
Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.
BACKGROUND Individuals with severe generalized recessive dystrophic epidermolysis bullosa (RDEB), an inherited blistering disorder caused by mutations in the COL7A1 gene, develop unexplainedExpand
  • 39
  • 3
Development and implementation of a three-choice serial reaction time task for zebrafish (Danio rerio)
Zebrafish are an established and widely utilized developmental genetic model system, but limitations in developed behavioral assays have meant that their potential as a model in behavioralExpand
  • 43
  • 3