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Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation of Arc Synthesis
Brain-derived neurotrophic factor (BDNF) is implicated in long-term synaptic plasticity in the adult hippocampus, but the cellular mechanisms are little understood. Here we used intrahippocampalExpand
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BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis
Interest in BDNF as an activity-dependent modulator of neuronal structure and function in the adult brain has intensified in recent years. Localization of BDNF-TrkB to glutamate synapses makes thisExpand
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Sustained Arc/Arg3.1 Synthesis Controls Long-Term Potentiation Consolidation through Regulation of Local Actin Polymerization in the Dentate Gyrus In Vivo
New gene expression is necessary for long-term potentiation (LTP) consolidation, yet roles for specific activity-induced mRNAs have not been defined. Here we probed the dynamic function ofExpand
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The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function
In a manner unique among activity-regulated immediate early genes (IEGs), mRNA encoded by Arc (also known as Arg3.1) undergoes rapid transport to dendrites and local synaptic translation. DespiteExpand
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Dendritic mRNA: transport, translation and function
Many cellular functions require the synthesis of a specific protein or functional cohort of proteins at a specific time and place in the cell. Local protein synthesis in neuronal dendrites isExpand
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Brain-Derived Neurotrophic Factor Triggers Transcription-Dependent, Late Phase Long-Term Potentiation In Vivo
Acute intrahippocampal infusion of brain-derived neurotrophic factor (BDNF) leads to long-term potentiation (BDNF-LTP) of synaptic transmission at medial perforant path→granule cell synapses in theExpand
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The Arc of synaptic memory
The immediate early gene Arc is emerging as a versatile, finely tuned system capable of coupling changes in neuronal activity patterns to synaptic plasticity, thereby optimizing information storageExpand
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From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning.
One of the most rigorously investigated problems in modern neuroscience is to decipher the mechanisms by which experience-induced changes in the central nervous system are translated into behavioralExpand
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Local protein synthesis, actin dynamics, and LTP consolidation
  • C. Bramham
  • Biology, Medicine
  • Current Opinion in Neurobiology
  • 1 October 2008
Modulation of local protein synthesis in neuronal dendrites plays a key role in the production of long-term, activity-dependent changes in synapse structure and functional efficacy. Such long-termExpand
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Dual regulation of translation initiation and peptide chain elongation during BDNF‐induced LTP in vivo: evidence for compartment‐specific translation control
Protein synthesis underlying activity‐dependent synaptic plasticity is controlled at the level of mRNA translation. We examined the dynamics and spatial regulation of two key translation factors,Expand
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